ISM-5411

Primary objectives: To evaluate the safety and tolerability of single and multiple oral administration of ISM5411 in healthy Chinese subjects. Secondary objectives: To evaluate the pharmacokinetic (PK) characteristics of ISM5411 and M15 (metabolite of ISM5411) in healthy Chinese subjects after single and multiple oral administration of ISM5411. To evaluate the effect of food on the PK characteristics of ISM5411 and M15 (metabolite of ISM5411) after a single dose of ISM5411 in healthy Chinese subjects. Exploratory objectives: To evaluate the changes in the expression of peripheral blood biomarkers (erythropoietin and vascular endothelial growth factor) and fecal biomarkers (calprotectin and lipocalin-2) in healthy Chinese subjects after single and multiple oral administration of ISM5411.