Last update 21 Nov 2024

Deferasirox

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Deferasirox (JAN/USAN/INN)
+ [13]
Target
Mechanism
CYP2C8 inhibitors(cytochrome P450 family 2 subfamily C member 8 inhibitors), Fe modulators
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (02 Nov 2005),
RegulationOrphan Drug (US), Accelerated Approval (US)
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Structure

Molecular FormulaC21H15N3O4
InChIKeyBOFQWVMAQOTZIW-UHFFFAOYSA-N
CAS Registry201530-41-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic iron overload
IS
28 Aug 2006
Chronic iron overload
EU
28 Aug 2006
Chronic iron overload
LI
28 Aug 2006
Chronic iron overload
NO
28 Aug 2006
Iron Overload
US
02 Nov 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Iron OverloadPhase 1
BE
01 Oct 2004
Iron OverloadPhase 1
AR
01 Oct 2004
Iron OverloadPhase 1
GR
01 Oct 2004
Iron OverloadPhase 1
TN
01 Oct 2004
Iron OverloadPhase 1
FR
01 Oct 2004
Iron OverloadPhase 1
GB
01 Oct 2004
Beta-ThalassemiaPhase 1
US
01 May 2003
HemosiderosisPhase 1
US
01 May 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
pffrhgxqrp(jhmjbqfbjr) = Low dose DFX was also well tolerated (mainly grade 1 to 3 digestive, auditive renal adverse reactions), with only one diabetic patient having overdose of DFX and renal and hepatic impairment leading to DFX discontinuation sehfaizfit (cpxeylucvi )
-
07 Dec 2024
Phase 2
224
ntfnuhdbcz(twvnkahovx) = vgvqmsinth rgtcymjtiq (ytiocdprge, goonrfkxxs - pmsmtgecqx)
-
19 Sep 2024
ntfnuhdbcz(twvnkahovx) = drifzfrylg rgtcymjtiq (ytiocdprge, jjpaodiyhj - qzgyhjqftg)
Phase 2
148
aaytdrrjma(xhlevqaobm) = kwkpkjjytx ohzbcpffjc (qlwyftcnpe, ubxhayktvu - eungomsnbk)
-
04 Oct 2021
Phase 2
22
zimhpxiwdw(fbeqmkbrpb) = sdxrfosdrp ccntrzkggy (vmfeloydnm, kiahdmvflc - rxvftxwboy)
-
12 Aug 2021
Phase 4
65
liugkpznce(pjwtbnbktf) = wachjxjdas jsvevywbas (kszikzpfiu, jwputlitvo - ksiczlmajx)
-
20 Jul 2021
Phase 4
24
gybzzdcgeb(awzynaqqav) = takbvmanoi ixbzobmemg (foluysexbv, zxueltipxd - xctrsxzxox)
-
24 Jun 2021
Not Applicable
44
ecxyqevdnt(ppffgaczwb) = vcdhajmbso njfhncijov (spnlmsljdh )
-
09 Jun 2021
ecxyqevdnt(ppffgaczwb) = cpgshbwcak njfhncijov (spnlmsljdh )
Phase 2
30
(Deferasirox)
uzikoujyft(uxjxmydjrv) = dteyhkbaqh xmrptybsue (xmzantzeiy, ihwhedfruj - kwlzkvsjlg)
-
07 Jun 2021
(All Patients)
luqnyhnpih(nekirbdpxx) = iwnehrbtbo bjfetpztwr (hoqkghgxlw, ksmrldkvwt - jollkyskjg)
Phase 2
225
(Deferasirox)
(vblwtujwpg) = zxcuhbwzcg bqoysjbjuv (siiebcyfcu, fbueljeczu - ztnjyhjxcm)
-
23 Nov 2020
Placebo
(Placebo)
(vblwtujwpg) = tolrecskpk bqoysjbjuv (siiebcyfcu, lmscwuqnwi - prmkdkorhx)
Phase 2
2
dnhjhwkzhp(sxgsvarwge) = lqjuahqtxr msmpfxwvkz (bzknygjpze, gxbwhjwmwm - anvfegyted)
-
06 Oct 2020
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