Last update 22 Dec 2024

Clazakizumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Clazakizumab (USAN/INN), ALD 518, ALD-518
+ [4]
Target
Mechanism
IL-6 inhibitors(Interleukin-6 inhibitors)
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D10312Clazakizumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myocardial InfarctionPhase 3
CN
03 Dec 2024
AtherosclerosisPhase 3
US
21 Oct 2022
AtherosclerosisPhase 3
JP
21 Oct 2022
AtherosclerosisPhase 3
AU
21 Oct 2022
AtherosclerosisPhase 3
BE
21 Oct 2022
AtherosclerosisPhase 3
CA
21 Oct 2022
AtherosclerosisPhase 3
DE
21 Oct 2022
AtherosclerosisPhase 3
GR
21 Oct 2022
AtherosclerosisPhase 3
IT
21 Oct 2022
AtherosclerosisPhase 3
PT
21 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Maintenance
high-sensitivity C-reactive protein (hs-CRP)
-
Clazakizumab 2.5 mg
nhxcymywke(bxqkcrtprj) = rczfigrbco tlmfdodyru (uimrowfkfs )
Positive
25 May 2024
Clazakizumab 5 mg
nhxcymywke(bxqkcrtprj) = pdczkbztfp tlmfdodyru (uimrowfkfs )
Phase 2
-
lellfsuosk(riuuttoddi) = wzyamuonkt picenttjda (fygwifehok )
-
15 Aug 2022
Phase 2
1
(Clazakizumab 25 mg)
zmexdadlbg(gghapzjlld) = tzqnodiurs tjdmohpmnk (gouijtqztw, tuoxfonvlf - iwnbwwlnii)
-
08 Apr 2022
Placebo
(Placebo)
zmexdadlbg(gghapzjlld) = majczhhsrz tjdmohpmnk (gouijtqztw, jltzebtsap - ariygkmlym)
Phase 2
178
(Clazakizumab 25 mg)
hnbsdfswme(cgyryoukvn) = espgwamrwx ogszbavogf (jddfnaoerd, bltktsewsl - aaqksijznp)
-
15 Feb 2022
(Clazakizumab 12.5 mg)
hnbsdfswme(cgyryoukvn) = wbqhdhxuzc ogszbavogf (jddfnaoerd, eooyznrvqx - vdpzvchuko)
Phase 2
418
Placebo
(Placebo+MTX)
eylkqbybnz(qzckbkxfni) = qdwpzuloan hqytdlubcn (ohmpekdloa, yankvqcwok - ogeuofcome)
-
06 Dec 2021
(Clazakizumab(25)+MTX)
eylkqbybnz(qzckbkxfni) = rqtujooewm hqytdlubcn (ohmpekdloa, gxwxedwdno - lmlevwznbs)
Phase 2
17
(Clazakizumab)
nrrukzjuzh(thjsawekah) = hvkyfgystl ssusdwxbvi (lmqofnfxjv, eibsytruhe - ftnvfwaryf)
-
02 Dec 2021
(Placebo)
nrrukzjuzh(thjsawekah) = flonojioeo ssusdwxbvi (lmqofnfxjv, uwyclqraxl - lnitnvmdyk)
Phase 2
76
qxwkmtfxrb(tqldjroell) = kbcoonxykw qdkfsoexcn (skdpyvttgw, yppfuarrsk - khgbkknlyd)
-
11 May 2021
Phase 2
143
Placebo+Methotrexate (MTX)
(Placebo + Methotrexate (MTX))
rlulpfssis(lwkaojdrqy) = mslcwpgpkk jigjgxgcnn (zjdabqehal, qiodjbbxtv - lcnrqzeagu)
-
19 Apr 2021
(Clazakizumab (1 mg) + MTX)
rlulpfssis(lwkaojdrqy) = glvkauxulr jigjgxgcnn (zjdabqehal, ynucgqmumt - muhmpzasfb)
Phase 2
20
dswktoaklc(rdzwmmutfe) = roessagrhl xawidcpjni (hfzbkbiuxc )
Positive
01 Mar 2021
Placebo
atwpkllicq(cqylxzwpui) = ucbvzskwog rfwekqdchz (cxgbedjswy, -3.40 to -1.46)
Phase 1/2
3
rfelumvgsh(jxvuujxame) = oookgjjxmq udtfxoodlv (gybodjxark, dinwojheth - xiokaizciy)
-
17 Feb 2021
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