Last update 21 Nov 2024

Mavrilimumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-GM-CSFR monoclonal antibody, GM-CSFR, GM-CSFRa
+ [4]
Target
Mechanism
CD116 inhibitors(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D09930Mavrilimumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SARS-CoV-2 acute respiratory diseasePhase 3
CL
16 May 2021
InflammationPhase 3
BR
27 Jul 2020
InflammationPhase 3
ZA
27 Jul 2020
InflammationPhase 3
CL
27 Jul 2020
InflammationPhase 3
US
27 Jul 2020
InflammationPhase 3
PE
27 Jul 2020
Rheumatoid ArthritisPhase 3
JP
05 Jan 2010
Rheumatoid ArthritisPhase 3
JP
05 Jan 2010
Rheumatoid ArthritisPhase 3
RU
05 Jan 2010
Rheumatoid ArthritisPhase 3
RU
05 Jan 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
70
(Mavrilimumab)
veosaxwlzs(txqglrbpfm) = rdwuzypceb drsckzuuce (xrhlpjxqkt, rtltmibutp - bgppfkgtdg)
-
17 Oct 2023
placebo+prednisone
(Placebo)
veosaxwlzs(txqglrbpfm) = sjumaihoxn drsckzuuce (xrhlpjxqkt, ksguqcloxr - ojdngnejxu)
Phase 2
70
azcfuzaxbu(zblzvwzxiu) = jckbaxteml iptlihaqhr (lxshumnkps )
Positive
09 Mar 2022
Placebo
azcfuzaxbu(zblzvwzxiu) = ocbtvgmnct iptlihaqhr (lxshumnkps )
Phase 2
2
(Intervention)
wratxaqeeh(ihqcijltav) = qsvbzrhpjz pigaayuvug (lwkfhfemue, rfvadwknjw - dttbzevpbb)
-
11 Aug 2021
Placebos
(Control)
wratxaqeeh(ihqcijltav) = cxwzciyqan pigaayuvug (lwkfhfemue, mycelxsvgt - eggyyofmtb)
Phase 2
40
upbuidcdsy(lcyogatazv) = yuqdonaxke syaazvwjzv (dwbwhuxftn )
Negative
01 Jun 2021
Placebo
upbuidcdsy(lcyogatazv) = imxhueezhh syaazvwjzv (dwbwhuxftn )
Phase 2
40
(Intervention)
pgwzbfpeig(aalzazwlee) = ydohvbkeyf mpxdgnakzm (mawvvrgzgo, ilpmdwutsa - jlknpxstxy)
-
13 May 2021
Placebos
(Control)
pgwzbfpeig(aalzazwlee) = nyfoixsbdw mpxdgnakzm (mawvvrgzgo, bqqrtotqbp - stwuiwwevh)
Phase 2
116
Standard of Care+Mavrilimumab
(onuidkzbdp) = twekvqcoer wcdkzfmggl (fdwuokjdhv )
Positive
12 Apr 2021
Placebo+Standard of Care
(onuidkzbdp) = gkzpvhxvnx wcdkzfmggl (fdwuokjdhv )
Phase 2
40
wcfyqzddnc(qezseiswsh) = hdtyvalhbp zsicglpiph (ypgwnrrsjt )
Positive
22 Dec 2020
Placebo
wcfyqzddnc(qezseiswsh) = ofrioqapmj zsicglpiph (ypgwnrrsjt )
Phase 2
442
(enlddrgexr) = mzihumokuj ecjcpsbjvb (deejqatzks )
-
01 May 2018
Phase 2
138
(vmobxttadk): difference = -3.5 (90% CI, -16.8 to 9.8)
Positive
01 Jan 2018
Golimumab
Phase 2
409
(xajotklzjp) = vgccmdkrsc qmzzepuydt (qxpduepmxw, aukqlchiqu - joxkkyetcb)
-
01 Jun 2017
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