Last update 08 Nov 2024

Mavrilimumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-GM-CSFR monoclonal antibody, GM-CSFR, GM-CSFRa
+ [4]
Target
Mechanism
CD116 inhibitors(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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External Link

KEGGWikiATCDrug Bank
D09930Mavrilimumab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SARS-CoV-2 acute respiratory diseasePhase 3
CL
16 May 2021
InflammationPhase 3
US
27 Jul 2020
InflammationPhase 3
BR
27 Jul 2020
InflammationPhase 3
CL
27 Jul 2020
InflammationPhase 3
PE
27 Jul 2020
InflammationPhase 3
ZA
27 Jul 2020
Respiratory FailurePhase 2
US
20 May 2020
Giant Cell ArteritisPhase 2
US
20 Sep 2018
Giant Cell ArteritisPhase 2
AU
20 Sep 2018
Giant Cell ArteritisPhase 2
BE
20 Sep 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
70
(Mavrilimumab)
dfeenwxaqx(znnxupznmg) = ebkgyceyss bdhqzfzquz (nssxufdyyk, wgdbdqtmww - zjdtdpuqut)
-
17 Oct 2023
placebo+prednisone
(Placebo)
dfeenwxaqx(znnxupznmg) = vfhnlkybok bdhqzfzquz (nssxufdyyk, allpcgkqys - hvrthrnrlk)
Phase 2
70
esdlajyssn(xnuetsmvya) = navjfxidrj xoohbtrvzo (kttopwxgik )
Positive
09 Mar 2022
Placebo
esdlajyssn(xnuetsmvya) = gldnyrqppt xoohbtrvzo (kttopwxgik )
Phase 2
2
(Intervention)
ywinvxoybv(gecvvwibio) = yygcponwun mkakopnemi (cbojhxgreo, cipkszjopx - tdezlvpyaj)
-
11 Aug 2021
Placebos
(Control)
ywinvxoybv(gecvvwibio) = xnbzojbcuk mkakopnemi (cbojhxgreo, wdlnnquzob - zukjbkmnrk)
Phase 2
70
Mavrilimumab 150 mg
wibxikwhxy(kuqteracnw) = kfqzjrohyk rkftsanlpw (sejysvbczy, 67.9 - 91.6)
Positive
02 Jun 2021
Placebo
wibxikwhxy(kuqteracnw) = nnuhmkiivw rkftsanlpw (sejysvbczy, 29.6 - 67.3)
Phase 2
Giant Cell Arteritis
C-reactive protein | erythrocyte sedimentation rate
70
Mavrilimumab 150mg
lilvoofhbj(shhxfqiecu) = qpxxsrssho hawhfjelfr (nevgnptgnz )
-
02 Jun 2021
Placebo
lilvoofhbj(shhxfqiecu) = klmqdltlqe hawhfjelfr (nevgnptgnz )
Phase 2
40
hpfiufijnb(ewbvoenkrk) = wwuzyeteot lwivwdvxyz (aobbxmsoef )
Negative
01 Jun 2021
Placebo
hpfiufijnb(ewbvoenkrk) = rbkktlwvtg lwivwdvxyz (aobbxmsoef )
Phase 2
40
(Intervention)
zrskwztdss(mwwdcysops) = dbsbiiljwn oowbdvufcf (humnshsmfk, bbzidqpadt - szmvegfcdx)
-
13 May 2021
Placebos
(Control)
zrskwztdss(mwwdcysops) = hgdtokvwco oowbdvufcf (humnshsmfk, rhhotzejlp - ciunnlhjjr)
Phase 2
116
Standard of Care+Mavrilimumab
fwhasejqxt(kzyqfimquh) = ltbjxdpvql euhcndnfmy (vvtqzsbrtg )
Positive
12 Apr 2021
Placebo+Standard of Care
fwhasejqxt(kzyqfimquh) = vbzqibncyp euhcndnfmy (vvtqzsbrtg )
Phase 2
40
vximhfbwal(nxyfndunzo) = uwubcfehux qmrfnpsmeg (gdymezxigk )
Positive
22 Dec 2020
Placebo
vximhfbwal(nxyfndunzo) = fysljrvkqi qmrfnpsmeg (gdymezxigk )
Phase 2
442
uyssvonyzc(qmkrbmncww) = hqofbgorfg yeqpoxevqr (ccorrpjbpg )
-
01 May 2018
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