Last update 20 Mar 2025

Pirarubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Adriamycin, tetrahydropyranyl, Pirarubicin, THP-Adm
+ [14]
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC32H38ClNO12
InChIKeyZPHYPKKFSHAVOE-YZIXBPQXSA-N
CAS Registry95343-20-7
View All Structures (2)

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Stomach Cancer
Japan
28 Aug 1992
Stomach Cancer
Japan
28 Aug 1992
acute leukemia
Japan
29 Mar 1988
Bladder Cancer
Japan
29 Mar 1988
Bladder Cancer
Japan
29 Mar 1988
Breast Cancer
Japan
29 Mar 1988
Breast Cancer
Japan
29 Mar 1988
Head and Neck Neoplasms
Japan
29 Mar 1988
Head and Neck Neoplasms
Japan
29 Mar 1988
Leukemia
Japan
29 Mar 1988
Lymphoma
Japan
29 Mar 1988
Lymphoma
Japan
29 Mar 1988
Ovarian Cancer
Japan
29 Mar 1988
Ovarian Cancer
Japan
29 Mar 1988
Transitional Cell Carcinoma
Japan
29 Mar 1988
Transitional Cell Carcinoma
Japan
29 Mar 1988
Uterine Neoplasms
Japan
29 Mar 1988
Uterine Neoplasms
Japan
29 Mar 1988
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
16
(klfxzquznh) = jzeyjynhxg xyhqgpkagq (sedvlovmit )
-
21 Sep 2022
Not Applicable
111
(owgxbvnqpl) = snrbwkxeso uocewteojt (gljwxjnimm )
-
01 Apr 2019
(owgxbvnqpl) = neakhxxxlj uocewteojt (gljwxjnimm )
Not Applicable
3
(lzmvcwejud) = wbqyojwxal tdjjpqtxkg (pwakrayshj )
Positive
01 Jun 2018
(lzmvcwejud) = ftvjshundg tdjjpqtxkg (pwakrayshj )
Not Applicable
160
(30 min intravesical THP retention time)
(avgresucwa): HR = 2.161 (95% CI, 0.4317 - 10.82), P-Value = 0.3484
-
01 Apr 2016
(120 min intravesical THP retention time)
Phase 2
77
THP instillation
ribouliyln(bnvyhmncqw) = mvplwcoqbu ucnfwertwy (jtsiggbypg )
-
10 Apr 2013
(Control group)
ribouliyln(bnvyhmncqw) = lqachqlyft ucnfwertwy (jtsiggbypg )
Phase 2
72
iptoqfenyu(zvvabzydfj) = fjxpkyixwt rtjshxinoa (jelrznthql )
-
01 Apr 2012
(No instillation)
iptoqfenyu(zvvabzydfj) = wqwtzndfex rtjshxinoa (jelrznthql )
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