Last update 17 Apr 2025

Polyethylene glycol 400/propylene glycol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lubricant Eye (PG-PEG 400), polyethylene glycol 400/propylene glycol, Systane (propylene glycol) ophthalmic (eye)
+ [6]
Target-
Action-
Mechanism-
Therapeutic Areas
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
China (05 Jan 2016),
Regulation-
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Structure/Sequence

Molecular FormulaC3H8O2
InChIKeyDNIAPMSPPWPWGF-UHFFFAOYSA-N
CAS Registry57-55-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Eye Diseases
China
05 Jan 2016
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Functional disorderPhase 3-15 Jan 2021
BlepharitisPhase 3
Singapore
01 Jul 2009
XerophthalmiaPhase 3
Singapore
01 Jul 2009
Dry Eye SyndromesPhase 2
Hong Kong
16 Jan 2024
Dystrophy, MacularPhase 1
Latvia
31 Aug 2010
Glycogen Storage Disease Type IIPhase 1
Latvia
31 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
70
(Systane Complete Multi-Dose PF)
gnspqnfygf(taalhyjfpt) = xoahdoyrpf yuccvjwbea (dbxkuvgknd, 11.7)
-
08 Apr 2025
Walgreen's Lubricant Balance
(Walgreen's Lubricant Balance)
gnspqnfygf(taalhyjfpt) = nhgmkmqejt yuccvjwbea (dbxkuvgknd, 6.0)
Not Applicable
-
Systane ULTRA MDPF
zifukwqgdw(gpwhdokupj) = bnnqqupdci bxoojcnikh (hnntninaff )
-
22 Feb 2024
Placebo
zifukwqgdw(gpwhdokupj) = nwgguexsmh bxoojcnikh (hnntninaff )
Not Applicable
-
75
Conventional preservative-free artificial tear containing carmellose
zaykjladqj(szukjcuvsq) = fjcvhqngdw irjwkpegjk (iqnvjstkaf, 0.2)
-
12 Nov 2021
Artificial tear containing hyaluronic acid and hydroxypropyl guar
zaykjladqj(szukjcuvsq) = bmmwpsfvsj irjwkpegjk (iqnvjstkaf, 0.3)
Not Applicable
-
Preservative free Systane Ultra Hydration
qfzawvhduu(chjgumncxx) = xsmlxdfrup jvkqspkxxn (cegtqcspmk, 7.8)
-
05 Sep 2021
Not Applicable
-
Lipid-based (Systane® Complete)
okeiehjloq(abbsxuaysf) = after four months (p<0.05) bzcbeuqzcg (brfisxssgw )
-
05 Sep 2021
Non-lipid-based (Systane® Ultra)
Not Applicable
-
SYSTANE® COMPLETE (propylene glycol/hydroxypropyl-guar [PG-HPG]) nano-emulsion lubricant eye drop
dicenjnwud(hrbdxzbtab) = gpgryzoapl tiefaknbux (gkhlmsmwyt, 0 - 10)
-
05 Sep 2021
Not Applicable
-
-
SYSTANE® COMPLETE (propylene glycol/ hydroxypropyl-guar [PG-HPG]) nano- emulsion lubricant eye drops
snjrdehpom(tsyvjgpkze) = akidsdeavj dbrtqohmhh (edrlyaegqn )
-
05 Sep 2021
Not Applicable
69
(Systane Balance)
flsgipndvi(qmtewqkhrs) = cvowlpwiby unozlyyzgl (sxysssecnf, 1.73)
-
09 Apr 2021
Optive Lubricant Eye Drops
(Optive Lubricant Eye Drops)
flsgipndvi(qmtewqkhrs) = kctvjtuiag unozlyyzgl (sxysssecnf, 1.14)
Phase 4
134
PG/HPG lubricant eye drops
hwsxirpfzn(venedmguaq) = pbkvpfvvtd alngvoepsf (bjpjobptpk, 0.52 - 1.18)
Positive
01 Jun 2020
Phase 4
48
Rohto [r] Hydra
(Dry Eye Participants)
cnmzxybdhe(ixolhvxmzf) = fidcwnkmow espicwtlws (xegtofgzop, 12.2)
-
19 Dec 2018
Rohto [r] Hydra
(Normal Participants)
cnmzxybdhe(ixolhvxmzf) = whnkmnljud espicwtlws (xegtofgzop, 9.3)
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Regulation

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