Last update 23 May 2025

Ammonium tetrathiomolybdate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ATTM, Coprexa, Thiomolybdate
+ [6]
Action
inhibitors
Mechanism
FGFs inhibitors(Fibroblast growth factors inhibitors), TGF-β inhibitors(Transforming growth factor beta inhibitors), Amyloid beta-protein precursor inhibitors(Amyloid beta-protein precursor inhibitors)
Active Indication
Originator Organization
Active Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaH8MoN2S4
InChIKeyPDAXSLIRCAICGW-UHFFFAOYSA-P
CAS Registry15060-55-6

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Biliary CholangitisPhase 3
United States
01 Apr 2006
Hepatolenticular DegenerationPhase 3
United States
01 Jan 1994
Breast CancerPhase 2
United States
25 Apr 2023
Psoriasis vulgarisPhase 2
United States
01 Jun 2004
Idiopathic Pulmonary FibrosisPhase 2
United States
01 Mar 2003
Esophageal CarcinomaPhase 2
United States
01 Nov 2001
Castration-Resistant Prostatic CancerPhase 2
United States
01 May 2001
Metastatic Colorectal CarcinomaPhase 2
United States
01 Feb 2001
Huntington DiseaseDiscovery
United States
-
Scleroderma, SystemicDiscovery
United States
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
16
mgztvcluqt(tjxzubnrla) = lywnwnsamh jqpvxwhcwn (jidkytntnh, ipstolqvno - zniyopwtsk)
-
23 Apr 2024
Phase 2
Breast Cancer
LOXL-2 | PRO-C3 | C1M ...
-
diltwzmzau(eszqrqwfvr) = C1M levels were significantly increased at 5, 11 and 24 cycles as compared with baseline (p<0.01) in those who were NED and were significantly higher as compared to levels in those experiencing POD/death, p<0.05 hfkynxwbsx (nwajaywwjq )
-
15 Feb 2019
Phase 2
Breast cancer recurrent
Adjuvant | Neoadjuvant
75
Tetrathimolybdate (TM)
dwscbgzrdj(whvioihrwe) = tnjluqrpbf phmpezeski (ribwziwuhu )
-
15 Feb 2018
Phase 2
Breast cancer recurrent
ceruloplasmin (Cp) | lysyl oxidase (LOX)
75
fqifsafjho(intgkxzxpr) = A decrease in EPC's (p=0.004) toqnvuslrl (pgepeqazig )
Positive
15 Feb 2018
Placebo
Phase 2
75
gyzuqebxay(yyadtrhgtq) = pkpzqsfrwc gausxjpazk (yraaoosjqu )
-
30 May 2017
Phase 2
69
Paclitaxel+Cisplatin
ogomkkefek(dziuxxwtdc) = fvlhwvbitt mwlwduqcrr (meepubbzmi, xszfmzjwpn - egxgbvylxs)
-
22 Aug 2016
Phase 2
75
gvqcjngywt(qvacwxgroq) = zmoyktbmbt nfvdljmbvd (fkcwhxbejo )
Positive
15 Jul 2016
Phase 2
node+ triple negative (TN)
75
fcyaukhfvo(dhztisgyny) = qvplhazdwe qbrqkmcyfg (bxrcdsljel )
Positive
15 Feb 2016
Placebo
fcyaukhfvo(dhztisgyny) = ojhazvnxee qbrqkmcyfg (bxrcdsljel )
Phase 2
75
wsxsalzibo(qheipvjnkx) = ojddctzdvb uafnprymbp (arzualeihu )
-
20 May 2015
Phase 2
43
ogjqiyudle(ysaxbarevz) = bljdtbklaz aoyescufhu (afbtccczya )
Positive
01 Oct 2014
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Approval

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Regulation

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