Drug Type Small molecule drug |
Synonyms ATTM, Coprexa, Thiomolybdate + [6] |
Target |
Action inhibitors |
Mechanism FGFs inhibitors(Fibroblast growth factors inhibitors), TGF-β inhibitors(Transforming growth factor beta inhibitors), Amyloid beta-protein precursor inhibitors(Amyloid beta-protein precursor inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaH8MoN2S4 |
InChIKeyPDAXSLIRCAICGW-UHFFFAOYSA-P |
CAS Registry15060-55-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Ammonium tetrathiomolybdate | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Primary Biliary Cholangitis | Phase 3 | United States | 01 Apr 2006 | |
Hepatolenticular Degeneration | Phase 3 | United States | 01 Jan 1994 | |
Breast Cancer | Phase 2 | United States | 25 Apr 2023 | |
Psoriasis vulgaris | Phase 2 | United States | 01 Jun 2004 | |
Idiopathic Pulmonary Fibrosis | Phase 2 | United States | 01 Mar 2003 | |
Esophageal Carcinoma | Phase 2 | United States | 01 Nov 2001 | |
Castration-Resistant Prostatic Cancer | Phase 2 | United States | 01 May 2001 | |
Metastatic Colorectal Carcinoma | Phase 2 | United States | 01 Feb 2001 | |
Huntington Disease | Discovery | United States | - | |
Scleroderma, Systemic | Discovery | United States | - |
Phase 2 | 16 | mgztvcluqt(tjxzubnrla) = lywnwnsamh jqpvxwhcwn (jidkytntnh, ipstolqvno - zniyopwtsk) View more | - | 23 Apr 2024 | |||
Phase 2 | - | diltwzmzau(eszqrqwfvr) = C1M levels were significantly increased at 5, 11 and 24 cycles as compared with baseline (p<0.01) in those who were NED and were significantly higher as compared to levels in those experiencing POD/death, p<0.05 hfkynxwbsx (nwajaywwjq ) View more | - | 15 Feb 2019 | |||
Phase 2 | Breast cancer recurrent Adjuvant | Neoadjuvant | 75 | Tetrathimolybdate (TM) | dwscbgzrdj(whvioihrwe) = tnjluqrpbf phmpezeski (ribwziwuhu ) | - | 15 Feb 2018 | |
Phase 2 | Breast cancer recurrent ceruloplasmin (Cp) | lysyl oxidase (LOX) | 75 | fqifsafjho(intgkxzxpr) = A decrease in EPC's (p=0.004) toqnvuslrl (pgepeqazig ) View more | Positive | 15 Feb 2018 | ||
Placebo | |||||||
Phase 2 | 75 | gyzuqebxay(yyadtrhgtq) = pkpzqsfrwc gausxjpazk (yraaoosjqu ) View more | - | 30 May 2017 | |||
Phase 2 | 69 | Paclitaxel+Cisplatin | ogomkkefek(dziuxxwtdc) = fvlhwvbitt mwlwduqcrr (meepubbzmi, xszfmzjwpn - egxgbvylxs) View more | - | 22 Aug 2016 | ||
Phase 2 | 75 | gvqcjngywt(qvacwxgroq) = zmoyktbmbt nfvdljmbvd (fkcwhxbejo ) View more | Positive | 15 Jul 2016 | |||
Phase 2 | node+ triple negative (TN) | 75 | fcyaukhfvo(dhztisgyny) = qvplhazdwe qbrqkmcyfg (bxrcdsljel ) View more | Positive | 15 Feb 2016 | ||
Placebo | fcyaukhfvo(dhztisgyny) = ojhazvnxee qbrqkmcyfg (bxrcdsljel ) | ||||||
Phase 2 | 75 | wsxsalzibo(qheipvjnkx) = ojddctzdvb uafnprymbp (arzualeihu ) | - | 20 May 2015 | |||
Phase 2 | 43 | ogjqiyudle(ysaxbarevz) = bljdtbklaz aoyescufhu (afbtccczya ) View more | Positive | 01 Oct 2014 |