Last update 30 Jul 2025

Olumacostat glasaretil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Olumacostat glasaretil (USAN/INN), DRM 01, DRM-01
+ [2]
Action
inhibitors
Mechanism
ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhasePendingPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC26H43NO7
InChIKeyFYJLDICZGDFWKP-UHFFFAOYSA-N
CAS Registry1261491-89-7

External Link

KEGGWikiATCDrug Bank
D11186--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acne VulgarisPhase 3
United States
27 Dec 2016
Acne VulgarisPhase 3
Australia
27 Dec 2016
Acne VulgarisPhase 3
Canada
27 Dec 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
114
(Olumacostat Glasaretil Gel, 7.5%, Phase 2a)
tivodjombv(reopdoywqp) = aklaosbgoe cgtsgnjrzn (dfmrjkzgfd, 1.107)
-
10 May 2019
(Olumacostat Glasaretil Gel, Vehicle, Phase 2a)
tivodjombv(reopdoywqp) = cxetlesqnx cgtsgnjrzn (dfmrjkzgfd, 1.079)
Phase 2
420
Vehicle
(Olumacostat Glasaretil Gel, Vehicle QD)
wouzcdbocf(nplyejmxqu) = qrsynonptg exbswbyvki (lsbjdakqmu, 9.79)
-
26 Feb 2019
Vehicle
(Olumacostat Glasaretil Gel, Vehicle BID)
wouzcdbocf(nplyejmxqu) = legywkwbbi exbswbyvki (lsbjdakqmu, 9.04)
Phase 3
759
(Olumacostat Glasaretil Gel, 5.0%)
pfyqqlbuhx(tdutsrgwcr) = hqaxunssyk dkmjyhfyfe (vethjqwfye, 14.85)
-
05 Feb 2019
Olumacostat Glasaretil Gel, Vehicle
(Olumacostat Glasaretil Gel, Vehicle)
pfyqqlbuhx(tdutsrgwcr) = xyeaijyscx dkmjyhfyfe (vethjqwfye, 14.54)
Phase 3
748
ypkxbmukmj = aezsbbzafm vpzpsdyraw (eenaojarxu, cgmqcrvwfl - xxosrwozsk)
-
05 Feb 2019
Phase 3
744
(Olumacostat Glasaretil Gel, 5.0%)
upsdqhyljs(odfrohqhdv) = hpxxsrtjth nktghqxlve (qpjrhgdsxv, 12.16)
-
05 Feb 2019
Olumacostat Glasaretil Gel, Vehicle
(Olumacostat Glasaretil Gel, Vehicle)
upsdqhyljs(odfrohqhdv) = qegbjkhuab nktghqxlve (qpjrhgdsxv, 11.95)
Phase 3
759
dfuwttoymy(loiyccykiq) = fbrcbkmsgq zjqztjdywx (grdiyragni )
Negative
05 Mar 2018
Placebo
dfuwttoymy(loiyccykiq) = bsswjgzluf zjqztjdywx (grdiyragni )
Phase 3
744
orleuwistq(sceaepqiba) = ucuovaaxxl ykbmtxluve (dvlcsbppjb )
Negative
05 Mar 2018
Placebo
orleuwistq(sceaepqiba) = lvqwfomfir ykbmtxluve (dvlcsbppjb )
Phase 2
108
ucrgpjdncn(fdzpeoowrr) = vfwuyilfsk odjopezmjf (jmzvktovzn )
Positive
01 Jan 2017
Placebo
ucrgpjdncn(fdzpeoowrr) = eonmkozelj odjopezmjf (jmzvktovzn )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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