Intensity-Modulated Radiotherapy Recommended for Locally Advanced Lung Cancer
09 Jul 2024
Clinical ResultPhase 3Radiation Therapy
TUESDAY, July 9, 2024 -- Intensity-modulated radiotherapy (IMRT) is recommended for locally advanced non-small cell lung cancer (NSCLC) and appears to have good long-term outcomes, according to a study published online June 27 in JAMA Oncology.
Stephen G. Chun, M.D., from The University of Texas MD Anderson Cancer Center in Houston, and colleagues compared long-term prospective outcomes of patients receiving IMRT and three-dimensional conformal radiotherapy (3D-CRT) with concurrent carboplatin/paclitaxel in a phase 3 randomized trial involving 483 patients with locally advanced NSCLC. Of the patients, 228 and 255 received IMRT and 3D-CRT, respectively. The percentage of an organ volume (V) receiving a specified dose of radiation in units of Gy was reported as V(radiation dose).
The researchers found that compared with 3D-CRT, IMRT was significantly associated with a twofold reduction in grade 3 or higher pneumonitis adverse events (3.5 versus 8.2 percent). Heart V20, V40, and V60 were associated with worse overall survival in a univariate analysis. Significantly reduced heart V40 was seen with IMRT versus 3D-CRT (16.5 versus 20.5 percent). Significantly better overall survival was seen with heart V40 (
"With a substantial number of patients reaching long-term survivorship for locally advanced lung cancer, cardiac exposure can no longer be an afterthought," Chun said in a statement.
Several authors disclosed ties to the biopharmaceutical and publishing industries.
Abstract/Full Text (subscription or payment may be required)
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Indications
Targets
-Chat with Hiro
Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.