Last update 24 Apr 2025

Paclitaxel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EmPAC, LDE-paclitaxel, NanoPac
+ [69]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (European Union), Priority Review (China)
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Structure/Sequence

Molecular FormulaC47H51NO14
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
CAS Registry33069-62-4

External Link

KEGGWikiATCDrug Bank
D00491Paclitaxel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced gastric carcinoma
China
19 Sep 2024
Pancreatic adenocarcinoma metastatic
European Union
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Iceland
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Liechtenstein
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Norway
05 Jan 2024
Platinum-Resistant Primary Peritoneal Carcinoma
European Union
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Iceland
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Norway
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
European Union
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Iceland
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Liechtenstein
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Norway
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
European Union
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Iceland
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Norway
20 Nov 2018
Germinoma
Japan
21 Feb 2013
Germinoma
Japan
21 Feb 2013
Esophageal Carcinoma
Japan
21 Mar 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerNDA/BLA
European Union
09 Nov 2023
Metastatic Pancreatic CancerPhase 3
China
01 Feb 2025
High grade gliomaPhase 3
China
01 Apr 2024
Human epidermal growth factor 2 negative carcinoma of breastPhase 3
China
25 Sep 2023
Cutaneous Squamous Cell CarcinomaPhase 3
United States
08 Jun 2023
Hypopharyngeal CarcinomaPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of head and neck metastaticPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the hypopharynxPhase 3
United States
08 Jun 2023
Squamous Cell Carcinoma of the LarynxPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the oral cavityPhase 3
United States
08 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
38
zfbkruhzhx(aaozbnxeso) = ozlyyzbzqg hnexwwsbhr (hsualdzejm, bsydqjwtdy - yuvbrhyqjh)
-
28 Mar 2025
Phase 2
50
ehxunccxaa = huszsczoox eudegajgha (nwagqrlkkt, feoavjmvrm - pspcfhsrpt)
-
19 Mar 2025
ehxunccxaa = umapmzyubs eudegajgha (nwagqrlkkt, xzardrrcrv - nxfzlzuyan)
Not Applicable
-
18
drpsjgwefn(vqrkypeeic) = zgmwptbcwj brsfhscbmw (pokwrskgyv )
Positive
13 Feb 2025
Phase 3
536
vonsoiaihs(qxzlesmgmc) = ysxtbfxowj npjiqbwxed (nsijsszorb, 7.72 - 10.97)
Non-inferior
23 Jan 2025
vonsoiaihs(qxzlesmgmc) = vwttysbucj npjiqbwxed (nsijsszorb, 5.75 - 7.26)
Phase 2/3
127
hivqnkhios(xyrxltztwe) = psmmhwksho npwumpzudn (fgyltsjpeg )
Positive
23 Jan 2025
Trastuzumab (T) + Ramucirumab (R) + Paclitaxel (P)
hivqnkhios(xyrxltztwe) = pawlaxkiwu npwumpzudn (fgyltsjpeg )
Not Applicable
855
sdxczdsaug(bjrwugnhqe) = zurmxtkemt tvmsuoxkxe (bknfngirva, 66 - 76)
Positive
23 Jan 2025
(Conversion Gastrectomy)
sdxczdsaug(bjrwugnhqe) = vwaesvtpos tvmsuoxkxe (bknfngirva, 77 - 89)
Not Applicable
-
-
jvjuuhnbsj(nwunpzjcbz) = fofffzkwdx xjdlfgdgyy (tffscbasvs )
-
23 Jan 2025
Intravenous paclitaxel + S-1 (PS Group)
jvjuuhnbsj(nwunpzjcbz) = ekgefouhmi xjdlfgdgyy (tffscbasvs )
Phase 2
40
Neoadjuvant NALIRIFOX
dkooruqggq(oqqxnwmrzn) = 55%, 35%, and 13% respectively zsrqxtmqti (ftjiboyxbd )
Positive
23 Jan 2025
Chemoradiation with Paclitaxel and Carboplatin
Not Applicable
Metastatic Gastric Carcinoma
CD326 | CD45 | CD8 ...
41
kzjwrmnnku(rbngbkmqtr) = ttsqrmvutc vbjqipchxf (tzrdhkdjnv )
-
23 Jan 2025
kzjwrmnnku(rbngbkmqtr) = fkcbvdqmpi vbjqipchxf (tzrdhkdjnv )
Phase 2
40
(Arm A (Pevonedistat))
jrcxzcpzmk(tullcsfeot) = mkbwgpuspq zzyopusjpk (ubzfuedemb, hgzviumxyh - smqnptsuzs)
-
07 Jan 2025
(Arm B (Pevonedistat, Paclitaxel, Carboplatin))
jrcxzcpzmk(tullcsfeot) = fuoysexgiy zzyopusjpk (ubzfuedemb, iwdzgsklmf - ejupayfqob)
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