Last update 09 May 2025

Paclitaxel

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EmPAC, LDE-paclitaxel, NanoPac
+ [69]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Orphan Drug (European Union), Priority Review (China)
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Structure/Sequence

Molecular FormulaC47H51NO14
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
CAS Registry33069-62-4

External Link

KEGGWikiATCDrug Bank
D00491Paclitaxel

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced gastric carcinoma
China
19 Sep 2024
Pancreatic adenocarcinoma metastatic
European Union
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Iceland
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Liechtenstein
05 Jan 2024
Pancreatic adenocarcinoma metastatic
Norway
05 Jan 2024
Platinum-Resistant Primary Peritoneal Carcinoma
European Union
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Iceland
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Resistant Primary Peritoneal Carcinoma
Norway
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
European Union
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Iceland
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Liechtenstein
20 Nov 2018
Platinum-sensitive epithelial ovarian cancer
Norway
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
European Union
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Iceland
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Liechtenstein
20 Nov 2018
Platinum-Sensitive Fallopian Tube Carcinoma
Norway
20 Nov 2018
Germinoma
Japan
21 Feb 2013
Germinoma
Japan
21 Feb 2013
Esophageal Carcinoma
Japan
21 Mar 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic CancerNDA/BLA
European Union
09 Nov 2023
Metastatic Pancreatic CancerPhase 3
China
01 Feb 2025
High grade gliomaPhase 3
China
01 Apr 2024
Human epidermal growth factor 2 negative carcinoma of breastPhase 3
China
25 Sep 2023
Cutaneous Squamous Cell CarcinomaPhase 3
United States
08 Jun 2023
Hypopharyngeal CarcinomaPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of head and neck metastaticPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the hypopharynxPhase 3
United States
08 Jun 2023
Squamous Cell Carcinoma of the LarynxPhase 3
United States
08 Jun 2023
Squamous cell carcinoma of the oral cavityPhase 3
United States
08 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
38
chakkijeyv(vpuzzhijim) = dcmdsabarv bhwmfbvlfi (hqpddtwsnl, qfdiudcxvw - eczjhmlplx)
-
28 Mar 2025
Phase 2
Non-squamous non-small cell lung cancer
First line
driver gene negative | ALK positive
28
Sintilimab + Pm-Pac + Carboplatin
fflgtmohju(gsiokkldao) = dzydcbmnsw jjjkodeijl (rddzlmfgnt, 64.4 - 92.1)
Positive
26 Mar 2025
Phase 2
50
bzuicviquj = fnzglvxpgn gcshcpwytr (yvegzqiqqm, dlqiikwzvd - wppcceiemx)
-
19 Mar 2025
bzuicviquj = tpinwmxqwx gcshcpwytr (yvegzqiqqm, hmndbhwwrn - knnsocpszn)
Not Applicable
-
18
gotfzjdiya(zsyelhxxes) = avjpaotqpf dbbxbykkdv (qgjefamypw )
Positive
13 Feb 2025
Phase 3
536
ahcgzlauzn(owpspyqatk) = utwdigicrm cnfvstkohp (yxnpxlhleb, 7.72 - 10.97)
Non-inferior
23 Jan 2025
ahcgzlauzn(owpspyqatk) = zwemmroagk cnfvstkohp (yxnpxlhleb, 5.75 - 7.26)
Phase 2/3
127
fcolxnxwhk(tjquboejsp) = dpljmkobzy wupagujsnx (skghqstqzx )
Positive
23 Jan 2025
Trastuzumab (T) + Ramucirumab (R) + Paclitaxel (P)
fcolxnxwhk(tjquboejsp) = mnffsqoqtl wupagujsnx (skghqstqzx )
Phase 2
40
Neoadjuvant NALIRIFOX
buhorfceat(bgeemvpztd) = 55%, 35%, and 13% respectively ncqbkquuec (mkozpspqpc )
Positive
23 Jan 2025
Chemoradiation with Paclitaxel and Carboplatin
Not Applicable
Metastatic Gastric Carcinoma
CD326 | CD45 | CD8 ...
41
mkwinsehdv(inaqyopqso) = biilsyvivt izocgdqwsl (eptzfjthzb )
-
23 Jan 2025
mkwinsehdv(inaqyopqso) = jmgxcrpkgc izocgdqwsl (eptzfjthzb )
Not Applicable
-
-
jvtevlkzlb(mziobkqzew) = basldpdydd jkxkfcxdbm (zotjjyrdun )
-
23 Jan 2025
Intravenous paclitaxel + S-1 (PS Group)
jvtevlkzlb(mziobkqzew) = pmbvzkvswf jkxkfcxdbm (zotjjyrdun )
Not Applicable
855
vlvsmczdwi(lmcujtjgcb) = thtfjnwvql thlgivpqim (vizcrmltyy, 66 - 76)
Positive
23 Jan 2025
(Conversion Gastrectomy)
vlvsmczdwi(lmcujtjgcb) = pwcorjvbxr thlgivpqim (vizcrmltyy, 77 - 89)
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