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Chinese biotech's MASH candidate reduces liver fat in phase 2 trial
18 Mar 2024
Drug ApprovalClinical ResultPhase 2
Chiglitazar has already been approved in China as a treatment for type 2 diabetes in addition to diet and exercise, with Chipscreen looking to expand its use in combination with anti-diabetic drug metformin.
ChiglitazarBiosciences' metabolic dysfunction-associated steatoheptype 2 diabetesandidate reduced patients' liver fat levels, adding further momentum to drugs aimed at the condition.metformin
Chipscreen Biosciencessemetabolic dysfunction-associated steatohepatitis (MASH)se-dependent reductions” in liver fat content from baseline compared to placebo during a phase 2 study, according to a Monday press release. The company did not provide data to support the primary endpoint win and said more will be revealed at an upcoming conference or in a medical journal. Chipscreen also reported that patients given chiglitazar “showed significant or dose-dependent trend of improvements” on a number of secondary endpoints.
As for safety, Chipscreen kept it shortchiglitazar “The overall safety is good.”chiglitazar
Chiglitazar has already been approved in China as a treatment for type 2 diabetes in addition to diet and exercise, with Chipscreen looking to expand its use in combination with anti-diabetic drug metformin.
Chiglitazarg of phase 2 data teased Monday comes days after Madrigtype 2 diabetesals scored the first-ever FDA approval to treat MASH, which has previously been known as non-alcoholic steatohepatitmetformin. The much-hyped class of GLP-1 medications have also shown promise as potential MASH treatments.
Chipscreen’s metabolic ambitions have grown in parallel withMadrigal Pharmaceuticalswork, centered on its eFDAenetic modulator, cMASHmide. The drug is approved in China anon-alcoholic steatohepatitis (NASH)lymphoma and breast cancerGLP-1 medicationsials testing it in patients with diffuse large B cell lymphoma and non-small cell lung cancer.
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