Designed to improve antibody-dependent cellular cytotoxicity (ADCC), AlloNK is a non-genetically modified, allogeneic, cord blood-derived, cryopreserved NK cell therapy candidate.
Artiva CEO Fred Aslan stated: “AlloNK given in combination with rituximab, an anti-CD20 antibody that targets B-cells, is already driving complete responses in late line B-NHL patients in an ongoing Phase I study by enhancing the activity of rituximab.
“Our hypothesis is that AlloNK plus rituximab also has the potential to drive deep B-cell depletion in LN patients with an off-the-shelf therapy that could be administered and managed in an outpatient setting.”
SLE is a severe autoimmune condition characterised by faulty B-cell activity and production of autoantibodies. Its clinical symptoms include end-organ damage and increased risk of death.
Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva.
Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content.
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