The COVID-19 vaccines currently being administered, or considered, in the MENA region
21 Jan 2021
VaccinemRNA
Over the past month, a number of COVID-19 vaccines have been approved for general or emergency use in the Middle East and North Africa (MENA). In our
previous article, we looked at the main 4 types of vaccine
– and the pros and cons of each one.
Now, using data collated by
the Vaccine Centre at the London School of Hygiene & Tropical Medicine
, along with various regional government media statements, we bring you a roundup of the actual COVID-19 vaccines currently circulating in the MENA. The most common ones at the moment, in no particular order, are by Sinopharm, Sinovac, Pfizer-BioNTech, Moderna, Oxford-AstraZeneca, and Sputnik V (Gamaleya Research Institute). Here’s what’s known about them.
Editor’s note: Information is accurate at time of publishing; however, given the ongoing updates in research – plus possible changes in governmental decisions – the availability and reliability of these vaccines is subject to change at any time
.
1) WHOLE VIRUS VACCINE
Sinopharm
(Beijing Institute of Biological Products)
Total number in registered trials:
56,128
Efficacy data:
79% in a press release; no supporting details reportedly provided
Storage requirements:
Refrigeration (2°C to 8°C)
Manufacture projections:
No official information; up to 1 billion doses in 2021 according to media reports
Approval status worldwide:
Full or emergency use in China
MENA countries using, approving or considering:
Bahrain, Egypt, Jordan (emergency use), Morocco, United Arab Emirates
Sinopharm
(Wuhan Institute of Biological Products)
Total number in registered trials:
52,864
Efficacy data:
Pending
Storage requirements:
Refrigeration (2°C to 8°C)
Manufacture projections
: Pending
Approval status worldwide:
Limited use in China
MENA countries using, approving or considering:
Limited use in United Arab Emirates
Sinovac
Total number in registered trials:
32,738
Efficacy data:
Pending
Storage requirements:
Refrigeration (2°C to 8°C)
Manufacture projections:
No official information; up to 600 million doses per year according to media reports
Approval status worldwide:
Limited use in China
MENA countries using, approving or considering:
Limited use in Egypt
2) RNA or mRNA VACCINE
Pfizer-BioNTech
Total number in registered trials:
45,838
Efficacy data:
95% based on primary efficacy analysis of 170 confirmed cases
Storage requirements:
Ultra-cold (-60°C to -80°C)
Manufacture projections:
Up to 1.3 billion doses in 2021
Approval status worldwide:
Full or emergency use in numerous countries; granted emergency use approval by the WHO on 31 Dec 2020
MENA countries using, approving or considering:
Bahrain, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Qatar, Kingdom of Saudi Arabia, Tunisia, United Arab Emirates
Moderna
Total number in registered trials:
33,720
Efficacy data:
94.5% based on interim data from 95 cases; these apparently included 11 cases of severe COVID-19, all of which occurred in the placebo group
Storage requirements
: Refrigeration (2°C to 8°C) for up to 30 days or frozen (-15°C to -25°C) for long-term storage
Manufacture projections:
Up to 1 billion doses per year
Approval status worldwide:
Full or emergency use in USA, Canada, EU, UK
MENA countries using, approving or considering:
Israel, Qatar
3) NON-REPLICATING VIRAL VECTOR
Oxford-AstraZeneca
Total number in registered trials:
68,066
Efficacy data:
62–90% based on interim data from 131 cases
Storage requirements:
Refrigeration (2°C to 8°C)
Manufacture projections:
3 billion doses in 2021
Approval status worldwide:
Emergency use in countries, including UK, India, Argentina, Dominican Republic, and El Salvador
MENA countries using, approving or considering:
Egypt (reportedly in talks), Libya (reportedly in talks)
Sputnik V (Gamaleya Research Institute)
Total number in registered trials:
45,086
Efficacy data:
91% in a press release; estimates based on 170 confirmed cases, including 20 cases of severe COVID-19, all of which occurred in the placebo group
Storage requirements:
Lyophilised formulation requires refrigeration (2°C to 8°C) or frozen formulation (maximum -18°C)
Manufacture projections:
No information on institute website; up to 1 billion doses in 2021 according to media reports
Approval status worldwide:
Early or emergency use in Russia, Belarus, Argentina, and Serbia
MENA countries using, approving or considering:
Algeria, Egypt (reportedly in talks), Palestine, United Arab Emirates (emergency use)
4) PROTEIN SUBUNIT
No COVID-19 vaccineCOVID-19 vaccine of this type is currently approved for widespread use.
On a final note, while some vaccines have been approved more quickly, that doesn’t necessarily signify anything in terms of efficacy or reliability. Ultimately, it is up to the user to decide which vaccine they would prefer.
For example, an mRNA vaccine has arguably been able to secure distribution before other vaccines due to the type of vaccine involved.
Gavi, the Vaccine Alliance (GAVI),
elaborates
: “Once a pathogen’s genome has been sequenced, it is relatively quick and easy to design a vaccine against any of its proteins... Moderna’s RNA vaccine against COVID-19 entered clinical trials within two months of the SARS-CoV-2 genome being sequenced.
“This speed could be particularly important in the face of new emerging epidemic, pandemic pathogens or pathogens which are rapidly mutating.”
Editorial note: This article has been updated on 22 January 2021.
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