Bristol Myers Squibb (BMS) and SystImmune have announced an exclusive licence and collaboration agreement worth up to $8.4bn for one of SystImmune’s cancer treatments, BL-B01D1.
ADCs are a new class of cancer therapies designed to precisely target and kill tumour cells while sparing healthy ones.
Data from earlier clinical studies of the candidate has demonstrated "promising anti-tumour activity" in patients with a range of solid tumours that had progressed after standard of care treatments, including NSCLC and breast cancer, AZ said.
“Recent BL-B01D1 trials have shown broad potential across different solid tumours as well as a manageable safety profile,” said Dr Yi Zhu, chief executive officer of SystImmune, adding that the collaboration is "an exciting step forward in delivering potential anti-tumour medicines to patients worldwide”.
Under the terms of the agreement, the companies will jointly develop and commercialise BL-B01D1 in the US, while SystImmune will retain exclusive rights in Mainland China and BMS will gain an exclusive licence in the rest of the world.
In exchange, BMS will pay SystImmune $800m upfront and up to $500m in contingent near-term payments, with SystImmune also eligible to receive additional up to $7.1bn based on the achievement of certain development, regulatory and sales performance milestones.
Samit Hirawat, executive vice president, chief medical officer, drug development at BMS, said: “SystImmune’s BL-B01D1 adds yet another ADC to our diverse pipeline and helps strengthen our approach of matching the most appropriate therapeutic modality to areas of unmet medical need across solid tumour oncology.
"We look forward to working with SystImmune to advance BL-B01D1 in hopes of offering a differentiated treatment option for patients in need.”
The agreement comes just over a month after BMS said it would be acquiring an experimental blood cancer therapy from Orum Therapeutics for up to $180m.
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.