Pitavastatin Cuts Risk of Cardiovascular Events in Patients With HIV
25 Jul 2023
AHAClinical StudyClinical Result
TUESDAY, July 25, 2023 -- For patients with HIV infection, those receiving pitavastatin have reduced risk of major adverse cardiovascular events over a median follow-up of 5.1 years, according to a study published online July 23 in the New England Journal of Medicine to coincide with the IAS Conference on HIV Science, held from July 23 to 26 in Brisbane, Australia.
Steven K. Grinspoon, M.D., from Massachusetts General Hospital in Boston, and colleagues randomly assigned 7,769 participants with HIV infection and a low-to-moderate risk of cardiovascular disease who were receiving antiretroviral therapy to receive daily pitavastatin calcium or placebo.
After a median of 5.1 years, the trial was stopped early for efficacy. The researchers found that the incidence of a major cardiovascular event was 4.81 and 7.32 per 1,000 person-years in the pitavastatin and placebo groups, respectively (hazard ratio, 0.65). Muscle-related symptoms occurred in 2.3 and 1.4 percent of the pitavastatin and placebo groups, respectively, and diabetes mellitus occurred in 5.3 and 4.0 percent, respectively.
"This observed reduction was larger than that predicted by the Cholesterol Treatment Trialists' Collaboration on the basis of the achieved reduction in low-density lipoprotein cholesterol levels," the authors write. "This finding suggests effects on cardiovascular risk beyond those associated with the lowering of LDL cholesterol alone."
Several authors disclosed ties to pharmaceutical companies, including Kowa Pharmaceuticals America, Gilead Sciences, and ViiV Healthcare, which supported the study.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information
Posted July 2023
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Targets
-Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.