Gilead, AstraZeneca/Daiichi Sankyo offer first look at TROP2 ADCs in first-line lung cancer as rivalry heats up
11 Sep 2023
ADCPhase 3Drug ApprovalAccelerated Approval
Preliminary mid-stage data from two rival TROP2-targeting ADCs advanced by AstraZeneca/Daiichi Sankyo and Gilead, combined with immune checkpoint inhibitors, have provided a first glance at the risk-benefit balance of this approach in non-small cell lung cancer. And although Gilead noticed a slightly higher response rate, analysts called the results “broadly similar.”
Both AstraZeneca’s Dato-DXd and Gilead’s Trodelvy comprise an antibody that targets the TROP2 receptor linked with a DNA topoisomerase 1 inhibitorDNA topoisomerase 1 inhibitor. Dato-DXd is an investigational program in Phase III for breast cancer and NSCLC, while Trodelvy is approved as a single agent for certain forms of breast cancer and has won accelerated approval for bladder cancer.
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