RS Oncology Data for Novel Treatment of Aggressive Cancers Selected for an Oral Presentation at ASCO Annual Meeting
01 May 2024
ASCOPhase 1Phase 2
Data from phase 1 clinical trial of RSO-021 selected for the Developmental Therapeutics session on June 3rd, 2024
Trial in progress for the ongoing expansion cohorts will be presented as a poster in the Lung Cancer session on June 3rd, 2024
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- RS Oncology, a clinical-stage biopharmaceutical company focused on developing novel treatments for aggressive and rare cancers, today announced that it will present the complete Phase 1 dose escalation data as an oral presentation at the world’s largest oncology meeting, the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.
The MITOPE phase 1 multicenter study, (clinical trials.gov #NCT05278975) investigating the safety and tolerability of RSO-021, is a first-in-human trial. RSO-021 is a first-in-class therapy for treatment of mesothelioma and solid tumors in patients with malignant pleural effusion. Professor Dean Fennell from Leicester Hospitals Trust in the UK will present the complete dose escalation data as part of a rapid oral session and answer questions during a moderated panel discussion.
Aggressive cancers present tremendous challenges in treatment and management, primarily due to rapid growth and spread to other parts of the body. Malignant pleural effusion (MPE) develops as a direct extension of cancer into the pleural space and is associated with shorter life expectancies. Currently, the phase 2 expansion portion of MITOPE is underway in the UK, exploring RSO-021 as both a single agent and in combination therapy to treat stage IV metastatic cancers with MPE, including mesothelioma, lung, breast and ovarian cancers. Other causes of MPE include cancer that has spread from the stomach, kidney, ovaries, and colon. Dr. Sean Dulloo from University of Leicester will present an update of the MITOPE Phase 2 trial as a trial-in-progress poster presentation.
The data is embargoed until published by ASCO 5:00 PM (EDT) on Thursday, May 23, 2024.
Details of the Presentations
Rapid Oral Abstract
Title: First-in-human phase 1 clinical trial of RSO-021, a first-in-class covalent inhibitor of mitochondrial peroxiredoxin 3 (PRX3), in patients with malignant pleural effusion due to mesothelioma and other advanced solid tumors (MITOPE).
Presenter: Dean Fennell
Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Day/Time: Monday, June 3, 9:06 am (session from 8:00-9:30 am)
Abstract #3019
Poster Presentation
Title: Phase 2 study to evaluate the novel mitochondrial PRX3 inhibitor, RSO-021, as an intrapleural monotherapy and in combination with IV paclitaxel in patients with malignant pleural effusion due to mesothelioma or another advanced solid tumor.
Presenter: Sean Dulloo
Session Title: Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers
Day/Time: Monday, June 3, from 1:30 - 4:30 PM CDT
Abstract: #TPS8124
Poster Bd: #381b
About RS Oncology
RS Oncology is a private, clinical-stage biopharmaceutical company leading scientific discoveries and global collaborations to improve the lives of patients with the aggressive cancers. Visit or follow us on LinkedIn and X.
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