Approximately 56,800 new cases of breast cancer are diagnosed in the UK each year, equating to more than 150 every day.
The growth of HR-positive breast cancer progression is often driven by oestrogen receptors (ERs), and endocrine therapies that target ER-driven disease are widely used as a first-line treatment in the advanced setting and often paired with CDK4/6 inhibitors. However, resistance to these therapies develops in many patients with advanced disease, at which point treatment options are limited and survival rates are low.
Truqap is given alongside AZ’s endocrine therapy Faslodex (fulvestrant) and works by blocking the effects of proteins called ATK kinases, which allow cancer cells to grow and multiply.
The MHRA’s decision is supported by positive results from the late-stage CAPItello-291 trial, in which Truqap plus Faslodex reduced the risk of disease progression or death by 50% compared with Faslodex alone in patients with tumours harbouring PI3K, AKT pathway or PTEN alterations.
David Harland, oncology medical affairs head, AZ UK said: “[Truqap] is a new treatment option which addresses the unmet needs of eligible HR-positive breast cancer patients with PIK3CA, AKT1, or PTENaltered tumours.
“These patients may often face limited options due to tumour progression or resistance to endocrine therapies.”
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