Last update 16 May 2025

Capivasertib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Capivasertib (JAN/USAN), Capivastertib, 卡帕塞替尼
+ [8]
Target
Action
inhibitors
Mechanism
Akt inhibitors(Proto-oncogene proteins c-akt inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (United States)
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Structure/Sequence

Molecular FormulaC21H25ClN6O2
InChIKeyJDUBGYFRJFOXQC-KRWDZBQOSA-N
CAS Registry1143532-39-1

External Link

KEGGWikiATCDrug Bank
D11371--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
ER-positive/HER2-negative Breast Cancer
European Union
17 Jun 2024
ER-positive/HER2-negative Breast Cancer
Iceland
17 Jun 2024
ER-positive/HER2-negative Breast Cancer
Liechtenstein
17 Jun 2024
ER-positive/HER2-negative Breast Cancer
Norway
17 Jun 2024
Breast Cancer
Canada
26 Jan 2024
Hormone receptor positive HER2 negative breast cancer
United States
16 Nov 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally advanced breast cancerPhase 3
Spain
07 Jan 2025
Advanced breast cancerPhase 3
China
26 Sep 2024
Metastatic castration-resistant prostate cancerPhase 3
United States
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
China
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Japan
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Australia
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Belgium
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Brazil
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Canada
25 Mar 2022
Metastatic castration-resistant prostate cancerPhase 3
Chile
25 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
Truqap + docetaxel + androgen-deprivation therapy
uulfwvzmfc(fhchbtzxvf) = unlikely meet the dual primary endpoints rneaogezro (ybepvjdxav )
Not Met
Negative
30 Apr 2025
placebo + docetaxel + androgen-deprivation therapy
Phase 2
25
Capivasertib 480 mg
kgujnunoku(fewblnwaio) = ckwgkbrenc apiuufndjr (diyjgprckp )
Positive
01 Mar 2025
Phase 3
708
Capivasertib 400 mg twice daily with fulvestrant
xxmzhqiofg(mzztdvgylc): HR = 0.6 (95% CI, 0.51 - 0.71)
Positive
01 Dec 2024
Placebo with fulvestrant
Phase 1
60
jbboxtxxxz(ywvrdtmskt) = bdmxwruiuh gflmduafmk (xtgbutkimz )
Positive
26 Nov 2024
jbboxtxxxz(ywvrdtmskt) = rutteadgcz gflmduafmk (xtgbutkimz )
Phase 3
Hormone-dependent prostate cancer
PTEN Deficient Expression
-
capivasertib + abiraterone + androgen deprivation therapy
jrduixaiyh(iadugiwtam) = statistically significant and clinically meaningful improvement dlrzemvbms (cfjysaixbo )
Positive
25 Nov 2024
placebo + abiraterone + androgen deprivation therapy
Phase 3
-
hvkginpslb(lidrysikyz) = The most common side effects experienced by participants included diarrhea eskaagpfmw (qaeapzehjz )
Positive
25 Nov 2024
Placebo plus Fulvestrant
Phase 3
Hormone receptor positive HER2 negative breast cancer
HER2 Negative | Hormone Receptor Positive
901
bbcxztehnl(bfxwvlrztv) = ponnexcvoi tembpjmhtj (xfntusvxbf, 9.1 - 16.7)
Positive
01 Sep 2024
placebo + fulvestrant
bbcxztehnl(bfxwvlrztv) = xlixkrxpuz tembpjmhtj (xfntusvxbf, 2.0 - 16.4)
Phase 3
923
Truqap (capivasertib) in combination with paclitaxel
fzynzwigfy(spbaknsglh) = did not meet the dual primary endpoints of improvement in overall survival (OS) nzakkidyna (jgjhbiqbks )
Not Met
Negative
18 Jun 2024
paclitaxel in combination with placebo
Phase 3
Hormone receptor positive HER2 negative breast cancer
HER2 Negative | Hormone Receptor Positive
708
(Overall population)
wwziodyrgw(hoxomteung) = wrimzlldql cbdpplztxw (dcfqulubaw )
Positive
16 May 2024
Placebo + Fulvestrant
(Overall population)
wwziodyrgw(hoxomteung) = lsfwvskcvn cbdpplztxw (dcfqulubaw )
Phase 3
-
qodnvbjckr(nqjguogocg) = Diarrhea (mostly grade 1) was the most frequent adverse event zygjjpikqe (tbrppcankw )
-
05 Dec 2023
Placebo + Fulvestrant
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