PXL065 is a new deuterium-stabilised R-stereoisomer of pioglitazone that exerts effects through several non-genomic pathways that are engaged by thiazolidinedione molecules.
It met the primary endpoint in a streamlined Phase II DESTINY-1 trial for NASH treatment.
Poxel CEO Thomas Kuhn said: “Orphan Drug Designation in adrenoleukodystrophy for both PXL770 and PXL065 further strengthens the value of these clinical assets where we are preparing to initiate Phase II proof-of-concept studies, pending additional financing.
“We are in active discussions to restructure our current debt obligations and secure the funding to execute our strategy in rare metabolic diseases”.
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