NeuroBo to Present Latest Pre-Clinical Data on Cardiometabolic Assets, DA-1241 and DA-1726, Targeting MASH and Obesity, at Scientific Conferences in June

30 Apr 2024
Phase 2Phase 1
CAMBRIDGE, Mass., April 30, 2024 /PRNewswire/ --
NeuroBo Pharmaceuticals, Inc. (Nasdaq: NRBO), a clinical-stage biotechnology company focused on the transformation of cardiometabolic diseases, today announced the acceptance of poster presentations for its promising cardiometabolic assets, DA-1241 and DA-1726, at the EASL Congress 2024 and the American Diabetes Association (ADA) 84th Scientific Sessions in June.
"Having multiple posters selected for presentation at two of the most esteemed scientific forums emphasizes the scientific community's recognition of the compelling pre-clinical data that we have generated for DA-1241 and DA-1726," stated Hyung Heon Kim, President and Chief Executive Officer of NeuroBo. "We have completed enrollment for Part 1 of our Phase 2a clinical trial of DA-1241, a novel G-Protein-Coupled Receptor 119 (GPR119) agonist for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). Additionally, we have recently dosed the first patient in the single ascending dose (SAD) Part 1 of our Phase 1 trial of DA-1726, a novel, dual oxyntomodulin (OXM) analog agonist that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR) for the treatment of obesity. DA-1726 has consistently shown, in our preclinical data, to sustain weight loss in diet-induced obese models by decreasing food consumption and boosting energy expenditure. Both programs are progressing well, and we have been able to significantly accelerate the clinical timelines for DA-1726. We currently expect to both dose the first patient in the multiple ascending dose (MAD) Part 2 and read-out top-line data from the SAD Part 1 in the third quarter of 2024, with top-line data from the MAD Part 2 expected in the first quarter of 2025."
June 5-8:
EASL Congress 2024. Members of the Dong-A ST Research Center and DA-1241 Phase 2 trial Contract Research Organization (CRO), Gubra, will present pre-clinical data on DA-1241, in two poster presentations at this congress in Milan, Italy.
Abstract Title: DA-1241, a GPR119 Agonist, Combined with Semaglutide Synergistically Improved Liver Fibrosis in Mice with CCl4-Induced Liver Fibrosis
Authors: Il Hoon Jung, Tae Hyoung Kim, Sujin Lee, Yuna Chae, Hyung Heon Kim, Mi-Kyung Kim
Presenter Name: II Hoon Jung, Dong-A ST Research Center
Abstract Number: 117
Session: Poster - Fibrosis / Stellate cell biology
Session Date: Thursday, June 6, 2024
Session Time: 8:30 am – 6:00 pm CET
Abstract Title: Additive Hepatoprotective Effects of DA-1241, a Novel GPR119 Agonist, in Combination with Semaglutide in the GAN Diet-Induced Obese and Biopsy-Confirmed Mouse Model of MASH
Authors: Monika Lewinska, Malte H. Nielsen, Susanne Pors, Henrik B. Hansen, Il Hoon Jung, Hyung Heon Kim, Michael Feigh, Mi-Kyung Kim
Presenter Name: Dr. Michael Feigh, Vice President Scientific Research, Gubra
Abstract Number: 1950
Session: Poster - MASLD: Experimental and pathophysiology
Session Date: Thursday, June 6, 2024
Session Time: 8:30 am – 6:00 pm CET
June 21-24:
American Diabetes Association (ADA) 84th Scientific Sessions. A member of the Dong-A ST Research Center will present pre-clinical data on DA-1726 in a poster presentation at this scientific session in Orlando, FL.
Abstract Title: DA-1726, a GLP1R/GCGR Dual Agonist, A Promising Approach in Obesity Treatment and Lipid Management
Presenter Name: Yuna Chae, DA-1726 Project Manager, Dong-A ST Research Center
Authors: Il-Hun Jung, Tae-Hyoung Kim, Su Jin Lee, Hyung Heon Kim, Mi-Kyung Kim, Yuna Chae
Abstract Number: 2024-LB-5728
Poster Presentation Number: 2058-LB
Session: 23-A Obesity-Animal
Session Date: Saturday, June 22, 2024
Session Time: 12:30 pm – 1:30 pm ET
After the presentations, the posters will be accessible within the "Presentations" section of NeuroBo's website at:
NeuroBo Pharmaceuticals, Inc. is a clinical-stage biotechnology company focused on transforming cardiometabolic diseases. The company is currently developing DA-1241 for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Type 2 Diabetes Mellitus (T2DM), and is developing DA-1726 for the treatment of obesity. DA-1241 is a novel G-protein-coupled receptor 119 (GPR119) agonist that promotes the release of key gut peptides GLP-1, GIP, and PYY. In preclinical studies, DA-1241 demonstrated a positive effect on liver inflammation, lipid metabolism, weight loss, and glucose metabolism, reducing hepatic steatosis, hepatic inflammation, and liver fibrosis, while also improving glucose control. DA-1726 is a novel oxyntomodulin (OXM) analogue that functions as a glucagon-like peptide-1 receptor (GLP1R) and glucagon receptor (GCGR) dual agonist. OXM is a naturally-occurring gut hormone that activates GLP1R and GCGR, thereby decreasing food intake while increasing energy expenditure, thus potentially resulting in superior body weight loss compared to selective GLP1R agonists.
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Marshall H. Woodworth
Chief Financial Officer
[email protected]
Michael Miller
[email protected]
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