Delving into the Latest Updates on Pondicherry Institute of Medical Sciences with Synapse

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Antimicrobial resistance (AMR) represents one of the most crucial public health threats worldwide. Hence, rapid detection of resistance patterns is of paramount importance. Vitek 2 AES (advanced expert system) can generate rapid and accurate AST reports, which can aid in starting the pathogen-directed treatment on time. We have analyzed the utility of Vitek AES in reporting various resistance patterns among gram-negative bacterial clinical isolates. About fifty multi-drug-resistant gram-negative bacterial isolates were subjected to AST testing by VITEK N407 card. The micro broth dilution method was used to estimate colistin minimum inhibitory concentration. The resistant phenotypes reported as per Vitek AES were documented and analyzed. Vitek AES grouped the resistance mechanisms into carbapenamase (58%), carbapenamase with AmpC (10%), carbapenamase with ESBL (12%), carbapenamase±ESBL (14%) and ESBL (6%). This study highlights using Vitek 2 AES as a rapid tool for reporting antimicrobial susceptibility and drug-resistant phenotypes.

28 Sep 2024·IP Indian Journal of Clinical and Experimental Dermatology

Application of microneedling radio frequency in treatment of acne scars- A case series

Author: Pavadai, Nithiyaa ; Paulprince, Sharone ; Vaishali, Trishna

Acne vulgaris is an chronic inflammatory disorder commonly seen in adolescents and is often self limiting. However post sequale of inflammation in acne can lead to scarring and severly affects quality of life of patients.There Herein, we describe four cases that showed satisfactory cosmetic results after the treatment of acne scars on forehead and malar area using a Micro needling radiofrequency. They were treated with 3 sessions of MNRF 4 weeks apart showed drastic improvement. Fractional microneedling radio frequency (MNRF) uses selective RF thermal zone creation without any epidermal or adnexal damage and causes neocollagenesis. MNRF is a recent advancement with superior efficacy with better compliance and lesser side effects.

28 Sep 2024·Indian Journal of Microbiology Research

A case series of brucellosis: A great mimicker

Author: Bhat, Sandhya ; Nair, Shashikala ; Phansalkar, Dilip Shankar ; Iqbal, Nayyar ; Solomon, Prince ; Dinakaran, Sridevi

Brucellosis is a common zoonotic disease worldwide. Although it is commonly neglected in India, there are pockets where it is prevalent. The disease tends to involve multiple organs, mimicking other illnesses. The symptoms are fever, sweating, and musculoskeletal pain. In 40-70% of patients, musculoskeletal involvement is the most common systemic manifestation. Blood culture, serological tests, and PCR are the available test formats for diagnosing brucellosis. Automated blood culture methods enable earlier diagnosis of brucellosis when presenting as a case of Fever of unknown origin (FUO). Here, we present four cases of brucellosis in a nonendemic area. Of these, two cases presented as spondylodiscitis, mimicking TB spine, one as endocarditis, and the other as acute brucellosis. All four cases were diagnosed with microbiological and radiological diagnostic support and successfully treated as per standard treatment guidelines. The possibility of brucellosis as a differential diagnosis in patients with nonspecific symptoms affecting the bones and unexplained prolonged fever should be considered.

100 Deals associated with Pondicherry Institute of Medical Sciences

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100 Translational Medicine associated with Pondicherry Institute of Medical Sciences

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