Barriers and Challenges of Loss to follow up, the healthcare utilization pattern, and healthcare expenditure among patients seeking treatment for hypertension at a tertiary care hospital A Mixed Method Study. - NIL

Start Date01 Feb 2025

Sponsor / Collaborator

Manipal college of Medical Sciences

CTRI/2024/11/077109

/ Not yet recruitingNot ApplicableIIT

Qualitative and Quantitative Assessment Of Microplastics in Urine - NIL

Start Date26 Nov 2024

Sponsor / Collaborator

Manipal college of Medical Sciences

CTRI/2024/10/076052

/ Not yet recruitingNot ApplicableIIT

Role of Micronutrient Levels on Cognitive Function and Quality of Life in Perimenopausal Women - NIL

Start Date16 Nov 2024

Sponsor / Collaborator

Manipal college of Medical Sciences

100 Clinical Results associated with Manipal college of Medical Sciences

0 Patents (Medical) associated with Manipal college of Medical Sciences

1,083

Literatures (Medical) associated with Manipal college of Medical Sciences

01 Apr 2025·Tissue and Cell

Characterizing thyroid follicles histogenesis in the human fetuses: A morphological approach

Article

Author: Poudel, Phanindra Prasad ; Kalthur, Sneha Guruprasad ; Pandey, Mahendra Raj ; Gupta, Chandni ; Bhattarai, Chacchu

Thyroid gland which is responsible for the maintenance of metabolism and growth is derived from thyroglossal duct, an outpocketing of foregut. The microscopic study of thyroid gland during development in first, second and third trimesters has utmost significance to understand the several developmental thyroid disorders metabolically and structurally. This study is descriptive observational study carried in tissue sections taken from thyroid gland of still birth and spontaneously aborted human fetuses of first, second and third trimester. The processed thyroid gland tissues were sectioned and conventional haematoxylin and eosin stain was used to study the detail histomorphology of this gland during these trimesters. Multiple shapes (round, oval and irregular) of thyroid follicles with variation in vascularity and fibrous capsule were observed in human fetuses during their development. Dimensions of epithelial cells (height and weight), outer and inner boundaries of thyroid follicles and number of parafollicular cells were increased as age progresses from first to third trimester whereas diameters, radius, perimeter, area and colloid volume of follicles were decreased as age progresses from first to third trimester. But the area of cytoplasm with nuclei (A_nc), cytoplasmic area (A_c) and nuclear-to-cytoplasmic (N/C) ratio were increased from first to second trimester thereafter decreased in third trimester. This study can act as baseline study to understand histomorphological differences in developing human fetal thyroid gland and to understand associated thyroid gland related disorders during its development.

01 Dec 2024·Non-coding RNA Research

Evaluation of circulating plasma miR-9, miR-29a, miR-192, and miR-375 as potential biomarkers for predicting prediabetes and type 2 diabetes in Nepali adult population

Article

Author: Manandhar, Krishna Das ; Manandhar, Binod ; Raut, Roji ; Dahal, Prajwal ; Pokharel, Daya Ram ; Adhikari, Shailesh ; Maskey, Abhishek ; Batajoo, Ashim ; Kafle, Ramchandra

Circulating plasma miRNAs have emerged as potential early predictors of glucometabolic disorders. However, their biomarker potential remains unvalidated in populations with diverse genetic backgrounds, races, and ethnicities. This study aims to validate the biomarker potential of plasma miR-9, miR-29a, miR-192, and miR-375 for early detection of prediabetes and type 2 diabetes mellitus (T2DM) in Nepali populations that represent distinct genetic backgrounds, races, and ethnicities. A total of 46 adults, categorized into healthy controls (n = 25), prediabetes (n = 9), and T2DM (n = 12) groups, were enrolled. Baseline sociodemographic, anthropometric, and clinical characteristics were collected. Fold change in plasma expression of all four miRNAs was quantified using RT-qPCR against the RNU6B reference gene. Their biomarker potential was determined by receiver operating characteristic (ROC) curve analysis. Multivariate discriminant function and hierarchical cluster analyses were used to evaluate the effectiveness of the miRNA panel in reclassifying study participants who were initially categorized according to their glucose tolerance status. Plasma expression of all four miRNAs was significantly upregulated in T2DM patients compared to normoglycemic controls. Furthermore, the expression of only miR-29a and miR-375 was upregulated in T2DM patients than in prediabetic individuals. Notably, only miR-192 expression was significantly upregulated in prediabetic individuals than in the normoglycemic controls. The miRNA expression profiles had the potential of reclassifying the participants into three original groups with an accuracy of 69.6 %. ROC curve analysis identified miR-192 as the predictor for both prediabetes and T2DM, while miR-9, miR-29a, miR-192, and miR-375 were predictive only for T2DM. The specific set of miRNA combinations significantly improved their predictive accuracy. This study validates the early predictive biomarker potential of plasma miR-9, miR-29a, miR-192, and miR-375 also in the Nepali population and paves the way for future translational studies to validate their utility in clinical laboratories.

12 Nov 2024·Circulation

Abstract 4144321: Catheter Ablation Outperforms Medical Therapy in Management of Persistent Atrial Fibrillation: Enhanced Cardiac Function, Reduced Mortality, and Lower Hospitalizationion Rates

Author: Sharma, Arundhati ; seelam, Laxmi Priya ; Daid, Simranpreet Singh ; Aryal, Saurav ; Panjiyar, Binay ; Sanghvi, Urja ; Dantuluri, Sahitya ; Syed, Saif ; Senthil Velmurugan, Isha ; Sharma, Anubhuti

Background: Persistent atrial fibrillation (AF) presents a significant management challenge, particularly in patients with concurrent heart failure. The effectiveness of catheter ablation compared to medical therapy for these patients remains under debate. Aim: This meta-analysis aims to evaluate the outcomes of catheter ablation versus medical therapy for managing persistent AF. Research Question: How does catheter ablation compare to medical therapy in managing persistent AF considering outcomes like arrhythmia recurrence, hospitalizations, cardiac function, exercise capacity, and mortality? Methods: We performed a meta-analysis of randomized controlled trials (RCTs) comparing catheter ablation with medical therapy in patients with persistent AF. Data sources included PubMed, Embase, Cochrane Library, Clinicaltrial.gov, Google Scholar, and CINAHL/EBSCOHOST, with studies selected based on predefined inclusion criteria. Primary outcomes assessed were recurrence of atrial arrhythmias, hospitalizations, changes in left ventricular ejection fraction (LVEF), changes in 6-minute walk test (6MWT) distance, and all-cause mortality. The data extraction was done using a spreadsheet, and the data analysis was done using RevMan 5.4.1: for meta-analysis Results: A total of 10 RCTs involving 1812 patients were included in the analysis. Compared to medical therapy, catheter ablation significantly reduced the recurrence of atrial arrhythmias (risk ratio [RR] = 0.43, 95% confidence interval [CI]: 0.29-0.63, P < 0.0001). Hospitalization rates due to heart failure were also lower in the ablation group (RR = 0.57, 95% CI: 0.44-0.73, P < 0.001). Improvements in LVEF were observed with a mean difference (MD) of 5.98% (95% CI: 3.81% to 8.15%, P < 0.00001). The performance on the 6MWT was better in the catheter ablation group, with an MD of 28.83 meters (95% CI: 8.61 to 49.05 meters, P = 0.005). Additionally, catheter ablation was associated with a reduction in all-cause mortality (RR = 0.60, 95% CI: 0.45-0.80, P = 0.00006). Conclusion: This meta-analysis demonstrates that catheter ablation is superior to medical therapy in managing persistent atrial fibrillation. Catheter ablation offers significant benefits in reducing atrial arrhythmia recurrence, lowering hospitalization rates, improving cardiac function and exercise capacity, and reducing mortality. These findings support the consideration of catheter ablation as a preferred treatment strategy for patients with persistent AF.

100 Deals associated with Manipal college of Medical Sciences

100 Translational Medicine associated with Manipal college of Medical Sciences

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