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Otorhinolaryngologic Diseases

Immune System Diseases

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Disease Domain	Count

Infectious Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

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H1 receptor(Histamine H1 receptor)	1

The liver occupies a central position in lipid and lipo-protein metabolism. Its function includes lipid and lipoprotein biosynthesis, assembly, packaging, transport, secretion, uptake and degradation of lipoproteins. In addition, enzymes synthesized and secreted by the liver into the blood stream or remaining bound to the endothelial cells in the capillaries, affect lipoprotein metabolism in the circulation. Xenobiotics may influence each of these steps. The mechanisms include more specific actions such as hormone or transmitter agonism and antagonism, membrane effects (stabilization or changes in trans-membrane gradients), influence on protein synthesis, influence on lipid metabolism by induction or inhibition of involved enzymes, or more general actions such as disturbances or damage of cellular membranes and cellular function. Some of these effects can easily be described as pharmacological actions, more or less independent of specific requirements in the chemical structure of the xenobiotics. Others are linked to specific chemical substituents such as carboxyl or alcoholic hydroxyl groups allowing the formation of lipid-xenobiotic-conjugates and/or the channeling of xenobiotics into lipid metabolism. This review will give a short overview of the mechanisms of xenobiotic-influenced hepatic lipid and lipoprotein metabolism.

01 Apr 1987·Planta MedicaQ3 · MEDICINE

Radioimmunoassay for the Quantitative Determination of Ajmaline

Q3 · MEDICINE

Article

Author: Deus-Neumann, B. ; Zenk, M. H. ; Arens, H.

A radioimmunoassay for the determination of pmol amounts of the indole alkaloid ajmaline (I) was developed.The antiserum was raised against a conjugate of I hemisuccinate-bovine serum albumin.The measuring range of the assay extends from 0.05 to 20 ng I, and as little as 150 fmol may be detected.The antiserum is highly specific for I, with only the I-isomers sandwicine, isoajmaline, and the unnatural 17-monochloroacetylajmaline showing substantial cross reactivity.This assay alows the rapid, sensitive and precise determination of I in unpurified extracts of whole plants as well as of cell cultures.The distribution of I in Rauwolfia plants, as well as the I production of Rauwolfia cell cultures, was investigated.The assay was used for studies to improve the Rauwolfia cell culture medium and a preliminary survey on the variability of I production in a population of Rauwolfia cells is given.

01 Dec 1986·Planta Medica

Novel Antiinflammatory Flavonoids fromPodophyllum versipelleCell Culture1¹

Article

Author: Parnham, M. J. ; Fischer, H. ; Ulbrich, B. ; Arens, H. ; Roemer, A.

Callus cultures, most of them from different plants species, were screened for antiinflammatory activity with the mouse macrophage chemiluminescence assay, an in vitro cellular test system.Only 2 of the secondary metabolite fractions from the cultures examined showed more than 60% inhibition of chemiluminescence (CL) at a concentration of 10^-5 mol/L.The most active culture, P. versipelle, was mass cultivated and 3 new flavonoids which were named podoverines A (I), B (II), and C were isolated from the cell mass by chromatog. on hydrophobic adsorbents.Podoverines A and B showed marked activity in the CL assay, with IC₅₀ values of 4.7 × 10^-6 and 6.4 × 10^-6 mol/L, resp., and are responsible for the activity of the corresponding callus culture.

100 Deals associated with A. Nattermann & Cie. GmbH

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100 Translational Medicine associated with A. Nattermann & Cie. GmbH

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Pipeline

Pipeline Snapshot as of 17 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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