YangLing Charisma Biopharmaceutical Co., Ltd.

Main purpose: Using phenarenic acid tablets (specification: 10 mg) of Xi'an Licai Pharmaceutical R&D Co., Ltd. as the test preparation and phenarenic acid tablets (trade name: Kerendia ®/Keshenda®, specification: 10 mg) certified by Bayer AG as the reference preparation, the bioequivalence of the two preparations in healthy human bodies was investigated according to the relevant provisions of the bioequivalence test. Secondary purpose: Observe the safety of the test preparation and the reference preparation in healthy subjects.

Primary study objectives: To study the pharmacokinetics of the test formulation upadacitinib extended-release tablets (specification: 15 mg, produced by Yangling Kesen Biopharmaceutical Co., Ltd.) and the reference formulation upadacitinib extended-release tablets (Rufu®, specification: 15 mg, produced by AbbVie Ireland NL B.V.) in healthy subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two formulations in the fasting and fed state. Secondary study objectives: To evaluate the safety of the test formulation upadacitinib extended-release tablets (specification: 15 mg) and the reference formulation upadacitinib extended-release tablets (Rufu®, specification: 15 mg) in healthy subjects.

The main purpose of the study is to investigate the pharmacokinetic characteristics of a single oral dose of 75 mg (fasting/postprandial) of the test preparation oseltamivir phosphate dry suspension (specification: 6 mg/ml, 60 mL/bottle, produced by Yangling Kesen Biopharmaceutical Co., Ltd.) and the reference preparation oseltamivir phosphate dry suspension (trade name: Tamiflu, specification: 6 mg/ml, 60 mL/bottle; produced by F. Hoffmann-La Roche Ltd.) in healthy adult Chinese subjects, and to evaluate the bioequivalence of the two preparations in fasting and postprandial states. Secondary purpose of the study: To evaluate the safety of a single oral dose of 75 mg (fasting/postprandial) of the test preparation and the reference preparation in healthy adult Chinese subjects.