Delving into the Latest Updates on ChoA Pharmaceutical Co., Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Neoplasms

Mouth and Tooth Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	1
Nervous System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

A1R x A2aR x Adenosine receptor x H1 receptor x PDE	1

This study was designed to investigate the effects of pyroligneous liquor on oxygen radicals and their scavenger enzymes in the liver of Cri/Bgi CD rats (7 rats per group).Male rats were fed a basic diet prepared in our Laboratory, PL-0 (Control), PL-1, PL-25, PL-50 and PL-75 groups were prepared to be 0%, 1%, 25%, 50% and 75% with distilled water using pyroligneous liquor (35% of Choa Co. Ltd.), and were administered orally for 8 wk.Superoxide radical contents in liver mitochondria and microsomes were significantly decreased to 12-14%, 11-15%, resp., in these PL-25 and PL-50 groups compared with the control group.Hydroxyl radical content in mitochondria and microsomes were markedly decreased to 12-20% and 17%, resp., in these PL-25 and PL-50% groups compared with the control group.Hydrogen peroxide content in mitochondria and microsomes were significantly decreased about 15-12% and 22-20% in liver of PL-25 and PL-50 groups compared with the control group.Mn-SOD and Cu/Zn-SOD activities in liver of PL-25 and PL-50 groups were remarkably increased to 15-25%, 11-16%, resp., compared with the control group.GPx activities in mitochondria and microsomes were significantly increased in the liver of PL-25 and PL-50 groups compared with the control group.CAT activities in mitochondria and cytosol were significantly increased to 12-14%, 15-27%, resp., in the liver of PL-25 and PL-50 groups compared with the control group.These results suggest that long term administration orally of 25 and 50% pyroligneous liquor may effectively inhibit the formation of oxygen free radicals, and also scavenger enzyme activities significantly increase through the administration orally.

100 Deals associated with ChoA Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with ChoA Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 22 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Caffeine/Dimenhydrinate/Pyridoxine Hydrochloride ( A1R x A2aR x Adenosine receptor x H1 receptor x PDE )	Motion Sickness More	Approved
Boric acid	-	Approved