Nostrum

Halle (Saale), Germany and Barcelona, Spain, September 06, 2023 – We are excited to announce a pioneering partnership between Nostrum Biodiscovery, a frontrunner in computational molecular engineering services, and Navigo Proteins, an innovator developing next generation targeting ligands called Affilin®. Navigo and Nostrum recently joined forces to co-develop a new cutting-edge pipeline of de novo designed ubiquitin-based Affilin® ligands, expanding Navigo’s proprietary Affilin® technology. With a small size, excellent stability, and high modularity, Affilin® are ideally suited for developing next-generation targeted therapeutics, like Affilin®- based radiotheranostics, drug conjugates and more. Combining artificial intelligence (AI) and molecular modelling (MM) tools with the Affilin® discovery platform, the collaboration aims to enhance the efficiency of developing novel binders with high affinity and specificity to a target protein. The concept relies on smartly designing sequences based on Navigo’s proprietary database, and then accurately predicting the fitness with MM approaches. Sergi Roda, Head of Protein Engineering at Nostrum Biodiscovery: “Thanks to the collaboration with Navigo Proteins, Nostrum Biodiscovery has been able to benchmark its AI+MM pipeline to design scaffold protein-based binders through experimental validation.” Dr. Ulrich Haupts, CSO at Navigo Proteins commented, “Due to their small size, Affilin® ligands are very well suited for modern AI-based approaches. In this mutually beneficial partnership, Nostrum’s technology provides an excellent opportunity to accelerate the Affilin® discovery process, and the know-how and infrastructure at Navigo, provide valuable feedback for optimization of Nostrum’s protein design approaches.” Despite many recent advances, the need for better solutions for cancer patients is still very high. This collaboration supports the fast and efficient development of targeted solutions like ADCs and radiopharmaceuticals by streamlining the Affilin® discovery process. Ultimately, the combined expertise of Nostrum Biodiscovery and Navigo Proteinsaims to enable a much faster development of Precision Medicines with a higher success rate than previously possible. About Navigo Proteins Navigo Proteins is a premier protein engineering company, discovering, and developing Precision Affinity Ligands. Precision Affinity Ligands are based on small, stable, and highly engineerable scaffold proteins and are functionalized for two different applications: As targeted next-gen therapeutics (PRECISION TARGETING); and for custom affinity purification of biologics (PRECISION CAPTURING®). Under the Precision Targeting Business Unit, Navigo is developing next-generation targeted therapeutics. Leveraging its long-standing expertise in protein engineering and drug design, Navigo develops Affilin® ligands using a state-of-the-art, fully automated, high throughput screening and selection technology employing large, ubiquitin-based libraries. Affilin® molecules can be customized as mono, bi-/ or multi-specific ligands which can be further coupled to various functional moieties like cytotoxic payloads and radioactive isotopes. With a clear focus in precision oncology and a drive to bring innovative, best-in-class therapies to patients, Navigo is developing novel Affilin® against Tumor Associated Antigens (TAAs) as well as immuno-oncology (I/O) targets. With a growing portfolio of Affilin® assets, and excellent pre-clinical data from in-house and partnered projects, Navigo is primed to advance Affilin®-based biopharmaceuticals into clinical development. For more information visit https://www.navigo-proteins.com/ and follow Navigo Proteins on LinkedIn. About Nostrum Biodiscovery Nostrum Biodiscovery is a spin-off from the Barcelona Supercomputing Center (BSC-CNS) and the Institute for Research in Biomedicine (IRB), two of the most recognized Spanish international research centers. Nostrum Biodiscovery provides advanced technologies in Molecular Modelling, with two areas of focus: therapeutics, e.g., small molecules design, targeted protein degradation, antibodies, immunologics and nucleic acids, and bio-based chemistry as in enzyme engineering. Nostrum Biodiscovery’s customer-tailored solutions are based on state-of-the-art proprietary and 3rd-party software, combined with the latest development on AI. Nostrum uses best in-class Molecular Modeling for data augmentation and fine-tuning of dedicated machine-learning algorithms. With a focus on efficiency, innovation, and accessibility, Nostrum Biodiscovery is committed to providing cutting-edge solutions to the global scientific community. Navigo Proteins Contact Dr. Priyanka Sahasrabudhe Sr. Business Development Manager BD@navigo-proteins.com Nostrum Biodiscovery Contact Head of Business Development Ali Hosseini ali.hosseini@nostrumbiodiscovery.com

NEW YORK, Nov. 1, 2022 /PRNewswire/ -- According to the recent study published by P&S Intelligence, the value of the sports nutrition market was about $38 billion in 2021, and it will reach over $78 billion by 2030, at a growth rate of over 8%. Sports Supplements Generating Highest Revenue Sports supplements had the largest share, in excess of 52%, in the past. This is mainly because of the increasing usage of protein supplements, especially whey protein, for strengthening the muscles by sportspersons and gym-goers. Additionally, the obtainability of numerous plant proteins, such as soy, pumpkin seeds, spirulina, rice, hemp, and peas, at retail platforms including Amazon and Walmart will support the increase in their sales. Get the sample pages of this report: Sports food will have the highest growth rate in the future, with energy and protein bars gaining popularity as on-the-go snacks. Likewise, the requirement for healthy snacking for managing weight is on the rise because of the growing occurrence of obesity. Post-Workout Supplements Are Highly Demanded Post-workout supplements are demanded the most, and thus, they held an over 34% share in the past. This is since these products repair injured muscles, improve muscle gain, aid energy recovery after strenuous physical activity, and maintain the mass of the muscles. Sports Nutrition Products Are Majorly Used by Adults Adults are the largest consumers of these products, credited to a large count of consumers in the age group of 18–64 years. Moreover, these consumers are actively involved in sports and fitness activities. Likewise, the increasing population of working women is escalating the demand for nutrition supplements. Additionally, adults will be the fastest-growing consumers in the near future. This is because of the increasing spending on health supplements, growing awareness concerning wellbeing, and rising demand for sugar-free and vegan supplements. Furthermore, the requirement for plant-based supplements is quickly increasing, and firms are addressing this trend by introducing compatible products. Browse detailed report on Sports Nutrition Market Size, Share and Demand Analysis Report 2022-2030 Powdered Supplements Are High in Demand Powdered supplements were demanded the most in the past because of the high-volume usage of protein powder. Furthermore, the usage of nutritional powders by fitness enthusiasts and athletes is increasing because of the innovations in powdered supplements, such as those used for making thick shakes. North America has the largest revenue share, of over 35%. This is credited to the growing requirement for supplements on account of the increasing awareness of people concerning health and the existence of numerous players. Europe will experience significant growth in the near future. This is because of the increase in sports participation and a growth in the count of initiatives taken by private and public organizations in regional countries to promote sound health. Global Sports Nutrition Market Report Coverage By Product Type Sports Supplements Sports Drinks Sports Foods Meal Replacement Products Weight Loss Products By Application Pre-workout Post-workout Weight Loss By Formulation Tablets Capsules Powder Softgels Liquid Gummies By Consumer Group Children Adult Geriatric By Activity Heavy users Light users By Distribution Channel Brick & Mortar Specialty Stores Small Retail Stores Fitness Institutes Grocery Stores General Discount Stores Discount Clothing Retailers E-Commerce Regional Analysis North America U.S. Canada Europe U.K. Germany France Spain Italy Asia-Pacific China India Japan South Korea Australia Latin America Brazil Mexico Middle East and Africa Saudi Arabia South Africa Browse More Reports Published by P&S Global Enteral Nutrition Market Size and Share Analysis Report, 2030 Global Clinical Nutrition Market Size and Share Analysis Report, 2030 Global Omega-3 Market Size and Share Analysis Report, 2030 About P&S Intelligence P&S Intelligence provides market research and consulting services to a vast array of industries across the world. As an enterprising research and consulting company, P&S believes in providing thorough insights on the ever-changing market scenario, to empower companies to make informed decisions and base their business strategies with astuteness. P&S keeps the interest of its clients at heart, which is why the insights we provide are both honest and accurate. Our long list of satisfied clients includes entry-level firms as well as multi-million-dollar businesses and government agencies. Contact: Prajneesh Kumar P&S Intelligence Phone: +1-347-960-6455 Email: [email protected] Web: Follow Us: LinkedIn Twitter Logo: SOURCE P&S Intelligence

Use in treatment of degenerative shoulder (glenohumeral) osteoarthritis generating steady revenue streams in shoulder replacement market; medical device companies offering customized prosthetics to capture value Prevalence of arthritis in elderly population presents vast avenue; popularity of reverse shoulder arthroplasty in patient population presents abundant opportunities; rise in healthcare spending enriching prospects of Asia Pacific market WILMINGTON, Del., Sept. 12, 2022 /PRNewswire/ -- Recent insights on the shoulder replacement market underscore the trend of rise in reverse shoulder arthroplasty in developed regions, particularly North America. Increasing adoption of customized prosthetics in the patient population has propelled sales of shoulder replacement market. The global market is forecast to advance at a CAGR of 6.9% from 2022 to 2031. Medical device companies are leaning on research & development activities to develop next-gen products for treatment of degenerative joint disorders in a bid to grow their market share for shoulder replacement. They are keen on developing products with lower failure rates and high safety profile in order to improve the overall patient outcomes. The market value of the shoulder replacement is expected to grow stridently on the back of commercialization of products with cutting-edge technology. Rise in number of people suffering from osteoarthritis in whom nonsurgical treatments have failed to show expected results is driving the expansion of the shoulder replacement market. Get Exclusive PDF Sample Copy of Shoulder Replacement Market Report - Key Findings of Shoulder Replacement Market Study Rise in Number of Reverse Shoulder Arthroplasty Generating Substantial Revenue Streams: Advancements in reverse shoulder arthroplasty techniques and technology presents vast lucrative opportunities for players in the market to capitalize on. Medical device companies are grabbing substantial revenue streams from the increased popularity of reverse total shoulder arthroplasty. The study authors observed that partial shoulder replacements have also risen, thereby presenting a lucrative avenue. Surgeons are presented with an opportunity to advance their skill sets, with support by governments. Adoption in Treatment of Degenerative Glenohumeral Diseases Propelling Growth: Steadily growing adoption of shoulder replacement in the treatment of degenerative glenohumeral diseases has propelled substantial revenue streams. Rise in demand for products in treating and managing degenerative shoulder disease will generate substantial revenue streams. The demand from elderly population presents a profitable avenue. Ask for References - Shoulder Replacement Market: Key Drivers Rise in incidence of degenerative shoulder (glenohumeral) osteoarthritis is a key driver of the shoulder replacement market. Sports injuries have contributed to a glaring prevalence of rotator cuff arthropathy and similar diseases in children and adolescents. Growing popularity of reverse shoulder arthroplasty surgeries in the target population has expanded the outlook of the shoulder replacement market considerably Shoulder Replacement Market: Regional Growth Dynamics North America held a major share of the global shoulder replacement market in 2021. Presence of globally prominent medical device manufacturers in the U.S. and Canada who are increasingly offering advanced products to treat traumatic and degenerative glenohumeral diseases is a major pivot for revenue generation. Rise in uptake of customized products has also fueled the growth of the North America market. The regional market on the back of these factors is estimated to retain its lead during the forecast period. Asia Pacific is a remarkably promising region in the global market. Rise in incidence of osteoarthritis, coupled with growing healthcare spending, is a key underpinning for profitable avenues for medical device companies, small as well as large players. Make an Enquiry Before Buying – Shoulder Replacement Market: Competition Landscape The TMR study on the global shoulder replacement market found that the competition landscape is highly fragmented, attributed to the presence of several players with significant stakes. Some of the key players in the shoulder replacement market are B. Braun Melsungen, Exactech, Wright Medical Group, Arthrex, Zimmer Biomet, Stryker, Smith and Nephew, Integra LifeSciences, and Johnson & Johnson. Shoulder Replacement Market Segmentation Procedure Total Shoulder Replacement Reverse Shoulder Replacement Partial Shoulder Replacement Shoulder Resurfacing Revision Shoulder Arthroplasty End-user Hospitals Ambulatory Surgical Centers Orthopedic Clinics Regions North America Latin America Europe Asia Pacific Middle East & Africa Countries U.S. Canada Germany U.K. France Spain Italy Russia & CIS Japan China India ASEAN Brazil Mexico GCC Countries South Africa Modernization of healthcare in terms of both infrastructure and services have pushed the healthcare industry to new heights, Stay Updated with Latest Healthcare Research Reports by Transparency Market Research: Gemcitabine HCL Market: The global gemcitabine HCl market is anticipated to reach more than US$ 1.3 Bn by 2031 with a CAGR of 7.8% from 2022 to 2031. Gout Therapeutics Market: The global gout therapeutics market is anticipated to reach more than US$ 4.9 Bn by the end of 2031 with a CAGR of 8.4% from 2022 to 2031. 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PET Radiotracer Market: The global PET radiotracer market is anticipated to reach more than US$ 3.2 Bn by the end of 2031 with a CAGR of 8.5% from 2022 to 2031. About Transparency Market Research Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants use proprietary data sources and various tools & techniques to gather and analyze information. Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. 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