Objective: To investigate the compatible stability of Xiyanping Injection in different dosages with 5% glucose injection and 0.9% sodium chloride injection.Methods: The changes before and after compatible application of Xiyanping Injection with 5% gucose injection and 0.9% sodium chloride injection (1:250, 2:250, 5:250, 10:250, 20:250, 30:250) on color, clarity, pH, main ingredients and atlas of HPLC were determinedResults: There were no difference in the color, clarity, pH, the main ingredients and ligredients and liquid fingerprints of the mixture solutions, but the insoluble particles in them showed significant difference within 6h.Conclusion: Xiyanping Injection is compatible in different concentrations with 5% glucose injection or 0.9% sodium chloride injection within 4h.It should be used with in 4h in practise, and the dosage of Xiyanping Injection should be less than 20mL every day.