Delving into the Latest Updates on Wayshine Biopharm with Synapse

Overview

Tags

Neoplasms

Nervous System Diseases

Respiratory Diseases

Small molecule drug

Biological products

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	4
Neoplasms	4

Top 5 Drug Type	Count

Small molecule drug	3
Biological products	1

Top 5 Target	Count

ATM(Serine-protein kinase ATM)	1
VEGFR2(Vascular endothelial growth factor receptor 2)	1
EGFR x EGFRvIII	1

主要目的：PartA：评价 WSD0922-FU 治疗非小细胞肺癌患者中的安全性和耐受性；PartB: 评价 WSD0922-FU 治疗晚期非小细胞肺癌患者的有效性次要目的：PartA：评价 WSD0922-FU 在非小细胞肺癌患者中的药代动力学特征；评价 WSD0922-FU 对非小细胞肺癌患者的初步有效性；PartB:评价 WSD0922-FU 治疗晚期非小细胞肺癌患者中的安全性和初步有效性

[Translation]

Primary objectives: Part A: Evaluate the safety and tolerability of WSD0922-FU in patients with non-small cell lung cancer; Part B: Evaluate the effectiveness of WSD0922-FU in patients with advanced non-small cell lung cancer Secondary objectives: Part A: Evaluate the pharmacokinetic characteristics of WSD0922-FU in patients with non-small cell lung cancer; Evaluate the preliminary effectiveness of WSD0922-FU in patients with non-small cell lung cancer; Part B: Evaluate the safety and preliminary effectiveness of WSD0922-FU in patients with advanced non-small cell lung cancer

Start Date30 Aug 2024

Sponsor / Collaborator

Pharmaron Beijing Co., Ltd.

[+1]

NCT06631989

/ RecruitingPhase 1/2

A Phase I/II Multicenter, Open Label, Single-arm Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of WSD0922-FU in the Treatment of Advanced Non-small Cell Lung Cancer

This study is a multicenter, open label, single-arm phase I/II clinical study of WSD0922-FU conducted in China, including Part A (dose escalation and expansion study) and Part B (dose extension). To explore the safety, tolerability, pharmacokinetic characteristics and efficacy of WSD0922-FU in patients with non-small cell lung cancer (NSCLC) with C797S mutation after first-line third-generation EGFR-TKI resistance (Osimertinib, Almonertinib, Furmonertinib, Befotertinib).

Start Date21 Aug 2024

Sponsor / Collaborator

Wayshine Biopharm

100 Clinical Results associated with Wayshine Biopharm

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0 Patents (Medical) associated with Wayshine Biopharm

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100 Deals associated with Wayshine Biopharm

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100 Translational Medicine associated with Wayshine Biopharm

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Pipeline

Pipeline Snapshot as of 04 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Preclinical

IND Approval

1

Phase 2 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

WSD-0922 ( EGFR x EGFRvIII )	Advanced Lung Non-Small Cell Carcinoma More	Phase 2 Clinical
WSD-0628 ( ATM )	Glioma More	IND Approval
WSD-1227 ( VEGFR2 )	Brain metastases More	Preclinical
WSD0329	Brain metastases More	Discovery