Impact of the multimodal anti-adhesive approach on the occurrence of postoperative small bowel obstructive complication after of colorectal cancer surgery: multicenter, prospective observational study

Start Date05 Feb 2024

Sponsor / Collaborator

Kyungpook National University Medical Center

KCT0008883 / Not yet recruitingNot Applicable

Post-transplant therapy with hypomethylating agent in Philadelphia chromosome negative adult acute lymphoblastic leukemia

Start Date01 Jan 2024

Sponsor / Collaborator

Kyungpook National University Medical Center

KCT0008624 / RecruitingNot Applicable

A Prospective, Multi-Center, Pilot study to Evaluate the Efficacy and Safety of Fexuprazan based 7 days triple therapy for Eradication of Helicobacter pylori Infections

Start Date11 May 2023

Sponsor / Collaborator

Kyungpook National University Medical Center

100 Clinical Results associated with Kyungpook National University Medical Center

0 Patents (Medical) associated with Kyungpook National University Medical Center

404

Literatures (Medical) associated with Kyungpook National University Medical Center

01 Dec 2023·Asia-Pacific Journal of Clinical Oncology

Prospective, open‐label, and observational study of cetuximab for metastatic colorectal carcinoma: The OPTIM1SE study

Article

Author: Chua, Clarinda ; Yang, Tsai-Sheng ; Ahn, Joong Bae ; Kim, Tae Won ; Lin, Johnson ; Chen, Hong-Hwa ; Bo-Wen, Lin ; Lee, Myung-Ah ; Temraz, Sally ; Anh, Le Tuan ; Park, Young Suk ; Ho, Gwo Fuang ; Huang, Jason ; Kim, Jong Gwang ; Burge, Matthew

AbstractAimThe OPTIM1SE study observed long‐term real‐world outcomes of cetuximab‐based infusional 5‐fluorouracil (5‐FU) regimens for first‐line treatment of metastatic colorectal cancer (mCRC) across Asia‐Pacific and Middle East regions, aiming to characterize their use, effectiveness, and safety in routine practice.MethodsOPTIM1SE was a prospective, open‐label, observational study. Patients with untreated KRAS wild‐type mCRC and distant metastases were treated per locally approved labels and monitored for 3 years via electronic medical records. The primary endpoint was the overall response rate (ORR). Secondary endpoints included safety, progression‐free survival (PFS), and overall survival (OS).ResultsFrom November 19, 2013, to June 30, 2016, 520 patients were enrolled in 51 sites. Patients were mostly male (61.2%), with a mean age of 58.5 (±12.0) years; 420 patients received leucovorin, 5‐FU, and irinotecan–based regimens and 94 received leucovorin, 5‐FU, and oxaliplatin. The most common primary tumor site was the rectum (38.8%), with liver metastases (65.0%). ORR was 45.4% (95% CI, 41.1%–49.7%), including 26 patients (5.0%) with a complete response. Median PFS was 9.9 months (95% CI, 8.2–11.0); median OS (mOS) was 30.8 months (95% CI, 27.9–33.6). Higher mOS was associated with tumors of left compared with right‐sided origin (hazard ratio, 0.69 [95% CI, 0.49–0.99]); higher ORR was also associated with liver metastases compared with all other metastases (55.4% vs. 40.2%). Adverse events were consistent with the known safety profile of cetuximab.ConclusionCetuximab‐based 5‐FU regimens were effective first‐line treatments for mCRC in routine practice, particularly in patients with left‐sided disease and liver metastases only.

05 Oct 2023·Journal of the Endocrine Society

FRI116 Inhibition Of Mitochondrial Fission And Restoration Of Mitochondrial Function Attenuates Vascular Calcification

Author: Jeon, Jae-Han ; Kim, Min-Ji ; Lee, In-Kyu ; Kim, Seahan ; Hee Kwon, So ; Jueun, Byun ; Zerwa, Siddique

AbstractDisclosure: S. Kwon: None. M. Kim: None. S. Zerwa: None. S. Kim: None. B. Jueun: None. J. Jeon: None. I. Lee: None.Objectives: Vascular calcification is associated with cardiovascular disease mortality, especially in patients with diabetes mellitus and chronic kidney disease. One of proposed mechanisms for development of vascular calcification suggested mitochondrial dysfunction of vascular smooth muscle cells (VMSCs), especially excessive mitochondrial fission that led to apoptosis and tissue calcium deposit formation. In existing literature, Vitamin B1 inhibited mitochondrial fission and improved mitochondrial function. This study investigated whether inhibiting mitochondrial fission prevents vascular calcification in vitro and in vivo by using inorganic phosphate and cholecalciferol-induced vascular calcification models, respectively. Methods: VMSCs from thoracic aorta of 4-week-old rats were treated by 2.6mM inorganic phosphate and 2mM calcium chloride to induce calcification. 6-week-old male C57BL/6J mice were given vitamin B1 analogue solution or water with daily oral gavage for 13 days, then aortic calcification was induced by subcutaneous injection of 5.5×10-5 IU/kg cholecalciferol for 3 days before sacrifice. Cells and tissues were stained for calcium deposition, (van Kossa stain), apoptosis (TUNEL) and mitochondrial morphology (Mitotracker). Western blotting and quantitative real-time PCR were used to assess calcification pathways and mitochondrial function. Tissue calcium content, normalized with total protein contents, was measured to quantify the extent of calcification. Mitochondrial oxygen consumption ratio (OCR) and mitochondrial membrane potential (JC-1 dye staining) were assessed to analyze quantified mitochondrial function. Results: Calcium deposition in both in vivo and in vitro models were alleviated by vitamin B1 analogue through inhibition of mitochondrial fission and restoration of mitochondrial function. In addition, vitamin B1 analogue downregulated expression of genes related to calcification and osteogenesis, such as bone morphogenic protein 2, osteocalcin, osteopontin, and runt-related transcription factor 2. Conclusion: Prevention of mitochondrial dysfunction in VSMCs may be a viable therapeutic strategy for treatment of vascular calcification.Presentation: Friday, June 16, 2023

03 Oct 2023·BJS open

Short-term outcomes of Early versus conventional adjuvant chemotherapy in stage III colon cancer: randomized clinical trial.

Article

Author: Park, Jun Seok ; Bae, Ki Beom ; Lee, Kyung Ha ; Choi, Gyu-Seog ; Kang, Byung Woog ; Lee, Yoon Suk ; Son, Gyung Mo ; Bae, Sung Uk ; Kim, Ji Yeon ; Kim, Jong Gwang ; Song, Seung Ho ; Baek, Seong Kyu ; Park, Soo Yeun ; Lee, In Kyu ; Kim, Hye Jin ; Kim, So Hyun

BACKGROUNDEvidence is lacking regarding the earliest timing of initiating adjuvant chemotherapy to maximize its efficacy safely. A trial was designed and conducted to evaluate the safety and oncological efficacy of early adjuvant chemotherapy compared with conventional adjuvant chemotherapy. The short-term outcomes are reported here.METHODSA multicentre, randomized (1 : 1), open-label, phase III trial was conducted comparing early adjuvant chemotherapy with conventional adjuvant chemotherapy in patients with stage III colon cancer. Patients who underwent radical surgery who had stage III colon cancer confirmed by histopathological assessment were screened and randomized into the early adjuvant chemotherapy arm or the conventional adjuvant chemotherapy arm. The primary endpoint was 3-year disease-free survival. The adjuvant chemotherapy with FOLFOX was delivered between postoperative day 10 and 14 in the early adjuvant chemotherapy arm, and between postoperative day 24 and 28 in the conventional adjuvant chemotherapy arm. Toxicity and quality of life were evaluated.RESULTSBetween 9 September 2011 and 6 March 2020, 443 patients consented to randomization at eight sites. The intention-to-treat population included 423 patients (209 in the early adjuvant chemotherapy arm and 214 in the conventional adjuvant chemotherapy arm), and the safety population included 380 patients (192 in the early adjuvant chemotherapy arm and 188 in the conventional adjuvant chemotherapy arm). There was no statistically significant difference in overall toxicity (28.1 per cent in the early adjuvant chemotherapy arm and 28.2 per cent in the conventional adjuvant chemotherapy arm, P = 0.244), surgical complications, and quality of life between the two arms.CONCLUSIONAdjuvant chemotherapy can be safely initiated 2 weeks after surgery with toxicity and quality of life comparable to conventional adjuvant chemotherapy for stage III colon cancer.

100 Deals associated with Kyungpook National University Medical Center

100 Translational Medicine associated with Kyungpook National University Medical Center

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