Article
Author: Miyagi, Yohei ; Rothman, Nathaniel ; Ji, Bu-Tian ; Liu, Li ; Chen, Ying ; Zhu, Junjie ; Hu, Zhibin ; Berndt, Sonja I. ; Guo, Huan ; Su, Jian ; Chen, Yuh-Min ; Blechter, Batel ; Wong, Jason Y Y ; Li, Xuelian ; Chen, Chung-Hsing ; Xu, Jun ; Wong, Maria Pik ; Minamiya, Yoshihiro ; Wong, Jason YY. ; Li, Shengchao A. ; Oh, In-Jae ; Kim, Young-Chul ; Lim, Wei-Yen ; Shen, Hongbing ; Yeager, Meredith ; Yang, Yang ; Shimizu, Kimihiro ; Gao, Yu-Tang ; Watanabe, Shun-ichi ; Chung, Lap Ping ; Kubo, Michiaki ; Chen, Chien-Jen ; Kim, Jin Hee ; Wu, Yi-Long ; Kim, Yeul Hong ; Iwasaki, Motoki ; Yin, Zhihua ; Sung, Jae Sook ; Liu, Jianjun ; Man Ho, James Chung ; Landi, Maria Teresa ; Chen, Kun-Chieh ; Kunitoh, Hideo ; Wu, Chen ; Seow, Wei Jie ; Wang, Xiaoyu ; Wei, Fusheng ; Su, Wu-Chou ; Shiraishi, Kouya ; Wu, Guoping ; Stevens, Victoria L. ; Berndt, Sonja I ; Park, Kyong Hwa ; Yu, Chong-Jen ; Zheng, Wei ; Daigo, Yataro ; Song, Minsun ; Chien, Li-Hsin ; Chen, Kuan-Yu ; Tanaka, Kazumi ; Ren, Yangwu ; Kamatani, Yoichiro ; Choi, Yi Young ; Lin, Hsien-Chih ; Fei, Ke ; Cheng, Sensen ; Cai, Qiuyin ; Huang, Ming-Shyan ; Stevens, Victoria L ; Chanock, Stephen J. ; Lu, Daru ; Jiang, Gening ; Hsiung, Chao Agnes ; Choi, Jiyeon ; Tan, Wen ; Chen, Tzu-Yu ; Honda, Takayuki ; Yatabe, Yasushi ; Nakayama, Haruhiko ; Momozawa, Yukihide ; Matsumoto, Shingo ; Zhou, Baosen ; Hsiao, Chin-Fu ; Zheng, Hong ; Vermeulen, Roel C.H. ; Wang, Jiucun ; Dai, Juncheng ; Li, Jihua ; Hutchinson, Amy ; Yu, Jinming ; Park, Jae Yong ; Jung, Yoo Jin ; Li, Shengchao A ; Vermeulen, Roel C H ; Yang, Pan-Chyr ; Yamaji, Taiki ; Hicks, Belynda ; Matsuo, Keitaro ; Shi, Jianxin ; Choi, Jin Eun ; Takahashi, Atsushi ; Guan, Peng ; Goto, Akiteru ; Fraumeni, Joseph F. ; Chatterjee, Nilanjan ; Kim, Young Tae ; He, Qincheng ; Tsai, Ying-Huang ; Hong, Yun-Chul ; Xu, Ping ; Qian, Biyun ; Wu, Tangchun ; Kim, Hee Nam ; Jin, Li ; Kang, Chang Hyun ; Bassig, Bryan A ; Chang, Gee-Chen ; Chanock, Stephen J ; Goto, Koichi ; Yoon, Ho-Il ; An, She-Juan ; Fun Lee, Victor Ho ; Wu, Junjie ; Bassig, Bryan A. ; Chen, Hongyan ; Kweon, Sun-Seog ; Shin, Min-Ho ; Park, In Kyu ; Chan, John K.C. ; Zhang, Haoyu ; Wang, Junwen ; Song, Bao ; Wyatt, Kathleen ; Chen, Kexin ; Wu, Wei ; Liu, Jie ; Chen, Chih-Yi ; Burdett, Laurie ; Fraumeni, Joseph F ; Watanabe, Shun-Ichi ; Seow, Adeline ; Hosgood, H Dean ; Albanes, Demetrius ; Ma, Hongxia ; Tsuboi, Masahiro ; Zhang, Xu-Chao ; Wang, Zhehai ; Chang, Jiang ; Wang, Zhaoming ; Jeon, Hyo-Sung ; Loon Sihoe, Alan Dart ; Hu, Wei ; Kohno, Takashi ; Kim, Jun Suk ; Lan, Qing ; Chan, John K C ; Tsai, Fang-Yu ; Shu, Xiao-Ou ; Wang, Chih-Liang ; Sung, Sook Whan ; Lin, Dongxin ; Chang, I-Shou
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10-3). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.
