Topicality.Arterial hypertension remains one of the most common diseases in Ukraine.Pharmaceutical development provides creating effective, high-quality and safe medicines.Aim.To study the influence of quant. factors on pharmacotechnol. parameters of amlodipine with enalapril tablets.Materials and methods.We selected excipients grouped in 7 factors and studied them at the lower and upper levels.A random balance method used for the plan of the experimentThe obtained tablets have been analyzed according to the requirements of the State Pharmacopoeia of Ukraine.Significant factors have been determined by the scatter plots.Results and discussion.The excipients quantity influence on the pharmacotechnol. characteristics of the granulate (loss on drying), tablet mass (flowability, angle of repose, bulk d., tapped d.) and amlodipine with enalapril tablets (uniformity of mass, hardness, friability and disintegration) studied.Conclusions.It has been selected the number of excipients providing the pharmacotechnol. properties of the granulate, tablet mass and amlodipine with enalapril tablets according to current pharmacopoeia requirements.