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Nervous System Diseases

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σ1 receptor(Sigma opioid receptor)	1

BackgroundCulturally appropriate educational materials are necessary to improve health literacy among Indigenous populations. However, practically no such materials have been cross-culturally adapted and validated for Indigenous peoples based on compliance with efficacy components.ObjectiveTo perform a cross-cultural adaptation and validation of audiovisual educational materials for adult patients with rheumatoid arthritis belonging to Indigenous communities in Chiapas, Mexico.MethodsMixed-methods study consisting of three phases: 1) Spanish-Tzotzil translation and cross-cultural adaptation of seven previously designed and validated audiovisual educational materials; 2) qualitative validation; and 3) quantitative validation based on the efficacy components (attraction, understanding, induction to action, involvement, and acceptance). The information collected during the validation phases was recorded and transcribed for content analysis.ResultsA total of 31 patients with rheumatoid arthritis participated in the study. Patients had a mean age of 49 years, ≥5 years since disease onset, low adherence to pharmacological treatment (<20%), and a high level of illiteracy (>80%). After three versions of the educational material, where elements of cultural identification were added, the efficacy components increased significantly to reach scores higher than 90%. This suggests that culturally-adapted materials could promote greater patient participation in treatment.ConclusionThis study shows the importance of cross-cultural adaptation in the design and validation of audiovisual educational materials for Indigenous populations; this aspect should be considered when implementing educational strategies for patients with chronic diseases.InnovationFirst educational audiovisual material translated and adapted from Spanish to Tzotzil, with a cultural sensitivity approach to achieve educational goals and improve therapeutic adherence.

17 Mar 2025·Journal of Physics: Condensed Matter

Transfer matrix in graphene-like materials: the case of silicene and transition metal dichalcogenides

Article

Author: Rodríguez-Vargas, I ; Ibarra-Reyes, M ; Pérez-Álvarez, R

AbstractThe fundamental properties of 1D Dirac-like problems in silicene and transition metal dichalcogenides (TMDs) are derived with the use of the transfer matrix. Analytic expressions for the transmission coefficient and the bound states are obtained for these 2D materials. The continuity between states of perfect transmission and bound states is also addressed in silicene and TMDs. The similarities and differences with respect to the fundamental properties of 1D Dirac-like problems in graphene derived with the transfer matrix (Ibarra-Reyes et al 2023 J. Phys.: Condens. Matter35 395301) are discussed.

01 Mar 2025·Inorganica Chimica Acta

Unsymmetrical Pt(II) pincer complexes of tridentate NN’S- and NN’Se-mono(iminophosphorane) ligands: Synthesis, characterization and solid state structure

Author: Grevy, Jean-Michel ; Rodriguez-Alvarez, Aurora ; Barba, Victor ; Hopfl, Herbert ; Martinez-De-Leon, Carla Gabriela

Four indole-substituted tridentate iminophosphorane ligands carrying NN′S- and NN′Se-donor atoms, i.e., HL^SMe, HL^SPh, HL^SeMe and HL^SePh, were prepared and combined with [Pt(SMe₂)₂Cl₂] to yield complexes of the compositions [Pt(L^SMe)Cl] (1a), [Pt(L^SPh)Cl] (1b), [Pt(L^SeMe)Cl] (2a) and [Pt(L^SePh)Cl] (2b).Product characterization by elemental anal., mass spectrometry, NMR spectroscopy (¹H/¹³C/³¹P) and single-crystal X-ray diffraction revealed complexes with metal ions embedded in unsym. square-planar coordination environments and largely planar ligand skeletons with extensive π-delocalization.The residual Pt-Cl bond and multiple options for ligand structure modification make this Pt(II) complex class promising for the future development of catalytic and pharmaceutical applications.

100 Deals associated with Universidad Autonoma Del Estado De Morelos

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100 Translational Medicine associated with Universidad Autonoma Del Estado De Morelos

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Pipeline

Pipeline Snapshot as of 28 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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