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Nervous System Diseases

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Disease Domain	Count

Nervous System Diseases	1

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Small molecule drug	1

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σ1 receptor(Sigma opioid receptor)	1

Background:Previously restricted to remote areas of Central and Western Africa, the MPOX virus-based disease, also known as monkeypox, has now spread to more than 90 countries and has become endemic. As a consequence, the MPOX virus has become a global public health concern.Objective:The objective of this study was to conduct a computational-multiparametric study (at the genomic and proteomic levels) of the biological sequences that express the MPOX virus envelopes in order to fathom the physicochemical regularities of these proteins.Methods:Using computer programs, we determined the polarity index method (PIM) profile and protein intrinsic disorder predisposition (PIDP) for each studied protein.Results:The UniProt database was able to identify sequences similar to those of the MPOX virus expressed thanks to the computational regularities found in the virus' envelope sequences.Conclusion:The polarity index method and protein intrinsic disorder predisposition profiles could aid in elucidating the sequence-level structural regularities of the MPOX virus envelopes.

01 Dec 2024·Fitoterapia

Vasorelaxant and tracheorelaxant effects of Bocconia arborea and their isolated benzophenanthridine alkaloids

Article

Author: Tlahuext, Hugo ; Arias-Durán, Luis ; Villalobos-Molina, Rafael ; Almanza-Pérez, Julio C. ; Almanza-Pérez, Julio C ; Estrada-Soto, Samuel ; Gaona-Tovar, Emmanuel ; Ramírez-Hernández, Armando

Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts. Thus, phytochemical bio-guided fractionation allowed the isolation of angoline (1), dihydrosanguinarine (2), bocconarborine A (3), oxisanguinarine (4), and oxychelerithrine (5) from dichloromethanic and methanolic extracts from the bark of Bocconia arborea (Papaveraceae). The relaxant study on aortic and tracheal rat rings of all benzophenanthridines indicates that 1 was the most active compound of the entire series investigated. Angoline (1) induces its relaxant effect by a concentration-dependent manner through the calcium channel blockade in both tissues.

01 Nov 2024·Human Dimensions of Wildlife

Social perceptions of wildlife management units in southern Morelos state

Author: López-Medellín, Xavier ; Sahagún-Padilla, Miguel Ángel ; Condori-Cordero, Samuel ; Valenzuela-Galván, David ; Blancas, José

100 Deals associated with Universidad Autonoma Del Estado De Morelos

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100 Translational Medicine associated with Universidad Autonoma Del Estado De Morelos

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Pipeline

Pipeline Snapshot as of 29 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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