Beijing Baiya United Medicine Research Institute Co.,Ltd.

The main purpose of the study is to study the pharmacokinetic characteristics of the test preparation tetrafenone soft capsule (specification: 15mg, license holder: Beijing Boya United Pharmaceutical Research Institute Co., Ltd.) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15mg, license holder: Eisai Co., Ltd.) in healthy subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations in the fasting and fed state. Secondary purpose of the study: to evaluate the safety of the test preparation tetrafenone soft capsule (specification: 15mg) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15mg) in healthy subjects.

A single-center, randomized, open, two-period crossover, single oral trial design was used to compare the differences in absorption extent and rate of guaifenesin bilayer sustained-release tablets (600 mg) provided by Beijing Boya United Pharmaceutical Research Institute Co., Ltd. and guaifenesin bilayer sustained-release tablets (600 mg, trade name: Mucinex®) produced by RB HEALTH US LLC in healthy Chinese people under fasting and postprandial administration conditions, and to evaluate the safety of guaifenesin bilayer sustained-release tablets provided by Beijing Boya United Pharmaceutical Research Institute Co., Ltd.

A single-center, randomized, open, three-period, partially repeated crossover, single-dose design was used to compare the differences in absorption extent and rate of pravastatin sodium tablets (specification: 40 mg) provided by Beijing Boya United Pharmaceutical Research Institute Co., Ltd. and pravastatin sodium tablets (trade name: Prareduct®; specification: 40 mg) produced by Daiichi Sankyo Belgium S.A. under fasting and postprandial administration in healthy Chinese people, and to evaluate the safety of pravastatin sodium tablets (specification: 40 mg) provided by Beijing Boya United Pharmaceutical Research Institute Co., Ltd.