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Overview

A randomized, double blind, placebo controlled clin. study was conducted on 41 women with cellulite aged between 31 and 50 years old. 21 of these were orally supplemented with SOD B Dimpless, a natural dry melon juice highly concentrated in SuperOxide Dismutase (SOD) at 40 mg per day (480 IU SOD), during 56 consecutive days.Cellulite was measured visually by scoring fat nodes on stomach and thighs, according to a linear scale.The oral supplementation with SOD B Dimpless significantly reduced cellulite on thighs compared to the placebo after 28 days.This reduction is amplified after 56 days of supplementation.The mechanism of action may involve the induction of endogenous antioxidant enzymes expression, leading to the inhibition of fibrosis and the stimulation of lipolysis.Further investigations are necessary to document the way of action of SOD B Dimpless against cellulite.

Journal of Physiobiochemical Metabolism

Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations

Author: Gilles Fouret ; Christine Feillet-Coudray ; B atrice Bonafos ; Jean Max Rouanet ; Charles Coudray ; Jean Paul Cristol ; Julie Carillon ; Dominique Lacan ; Thibault Sutra ; Caroline Laurent ; Manar Aoun

Xanthine Oxidase is Variably Involved in Nutritional and Physio-Pathologic Oxidative Stress Situations High random ROS production leads to generalised oxidative stress that is involved in aging and degenerative diseases, such diabetes or chronic kidney failure. The major cellular ROS sources are mitochondria and NADPH oxidase, and xanthine oxidase (XO). XO is known to be involved in ischemiareperfusion oxidative stress damages, but little is known about its possible involvement in other nutritional and physio-pathologic oxidative stress situations.

100 Deals associated with Bionov Sarl

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100 Translational Medicine associated with Bionov Sarl

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