Strand Therapeutics, Inc.

Company to present on STX-001 at ASCO 2024 BOSTON--(BUSINESS WIRE)-- Strand Therapeutics, the world’s first programmable mRNA company developing curative therapies for cancer, autoimmune diseases, and beyond, today announced the first patient has been dosed in their Phase 1, first-in-human trial of STX-001, an investigational multi-mechanistic, synthetic self-replicating mRNA technology that expresses an IL-12 cytokine for an extended duration, directly into the tumor microenvironment. “STX-001 represents the first programmable mRNA therapy in oncology to enter the clinic for the treatment of solid tumors,” said Jake Becraft, Ph.D., CEO & Co-Founder, Strand Therapeutics. “We are proud of this remarkable achievement for patients and for Strand Therapeutics to be able to take STX-001 from the lab to the clinic to evaluate the potential of this novel treatment approach for cancer patients with solid tumors.” STX-001 shows promise as a new approach to improve the efficacy of immunotherapy for solid tumors. In animal models, STX-001's self-replicating mRNA technology induced immunogenic cancer cell death and promoted recruitment of T cells and NK cells to the tumor microenvironment, as well as their activation, by directly expressing an IL-12 payload from the synthetic mRNA directly from the tumor cells themselves. “Significant progress has been made to date with current immunotherapies to address unmet patient needs in various solid tumors, but more work needs to be done to induce durable clinical responses in patients with minimal toxicities,” said Tasuku Kitada, Ph.D., Co-Founder, President, and Head of R&D, Strand Therapeutics. “We are eager to advance our work with STX-001 and continue to pioneer the development of programmable mRNA therapies to provide targeted and precise immune activation to the tumor microenvironment.” Strand at ASCO The first patient dosed with STX-001 comes days before the start of the American Society of Clinical Oncology (ASCO) Annual Meeting, taking place May 31 – June 4 in Chicago. Strand will present a poster on the Phase 1 trial design. The Phase 1 trial is an open-label, multi-center first-in-human dose-escalation trial, evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of STX-001 alone, or in combination with pembrolizumab in patients with treatment refractory advanced solid tumors. Details of the presentation are as follows: Presentation Title: A phase I trial of intratumoral STX-001: A novel self-replicating mRNA expressing IL-12 alone or with pembrolizumab in advanced solid tumors. Session Type: Poster Session Session Title: Developmental Therapeutics -- Immunotherapy Track: Developmental Therapeutics – Immunotherapy Sub-Track: New Targets and Technologies (IO) Session Date and Time: Saturday, June 1, 9:00AM – 12:00PM CDT Location: McCormick Place, Chicago, Illinois, Hall A Poster Board Number: 161b Permanent Abstract Number: TPS2696 Additional meeting information is available on the ASCO website. About Strand Therapeutics Strand Therapeutics is a next-generation biotechnology company committed to transforming the lives of patients by developing first-in-class programmable mRNA therapeutics. Founded by leaders in mRNA-based synthetic biology at MIT, Strand is creating the first platform for programmable, long-acting mRNA therapeutics that are bioengineered to enable precise control of the location, timing, intensity, and duration of therapeutic activity. Strand’s mission is to develop improved treatment options for cancer and other life-threatening diseases. The company is headquartered in Boston, MA. For more information, visit . Follow us @StrandTx.

mRNA, the messenger molecules transferring genetic instructions from DNA to ribosomes, is now at the forefront of pharmaceutical innovation. With mRNA therapeutics and vaccines emerging as game-changers, they offer a promising avenue for treating not only COVID-19 but also a spectrum of diseases, including infectious diseases, cancer, and genetic disorders. BOSTON, April 10, 2024 /PRNewswire/ -- "According to the latest BCC Research study, the demand for mRNA: Therapeutics and Global Markets is estimated to decrease from $33 billion in 2023 to reach $21 billion by 2028, at a compound annual growth rate (CAGR) of -8.6% from 2023 through 2028." This report delves into the mRNA therapeutics market, exploring various types of mRNA and their applications in therapy. It provides detailed insights into patent analysis and clinical trial analysis of mRNA, along with highlighting trends and dynamics influencing the market during the study period. The analysis extends to market projections up to 2028 and profiles key market players. Geographically, the market is segmented into North America, Europe, Asia-Pacific, and the Rest of the World (RoW), with estimations spanning until 2028. Additionally, BCC Research offers a comprehensive overview of industry acquisitions and strategic alliances from January 2020 to December 2022, identifying emerging trends in this activity. Explore the full report on the burgeoning mRNA Therapeutics Markets for comprehensive insights and forecasts – click here to Learn More. Market Drivers for mRNA Therapeutics Increasing Pandemics and Epidemics: The global landscape has witnessed a surge in pandemics and epidemics, prompting a heightened demand for innovative therapeutic solutions. mRNA-based vaccines and drugs have emerged as pivotal tools for swiftly responding to emerging infectious diseases, notably exemplified by their effectiveness against COVID-19. In response, governments and healthcare organizations worldwide are directing investments toward mRNA research, recognizing its potential to combat health crises effectively. Increasing Uptake of Vaccines: The remarkable success of mRNA vaccines like Pfizer-BioNTech and Moderna in combating COVID-19 has underscored the transformative potential of this technology. Consequently, public awareness and acceptance of mRNA-based vaccines have seen a significant uptick, fostering greater confidence in their efficacy and safety. This growing acceptance has not only propelled the widespread adoption of mRNA vaccines for COVID-19 but also laid the groundwork for their utilization against other diseases. Investment in mRNA Increasing: Biotech firms, research institutions, and pharmaceutical giants are funneling substantial investments into mRNA research and development initiatives. This funding is pivotal in supporting critical aspects such as clinical trials, manufacturing processes, and the scaling up of production for mRNA-based therapies. The surge in investment in mRNA technology is poised to drive innovation and broaden the scope of therapeutic applications, promising significant advancements in healthcare in the years to come. Request a Sample Copy of the mRNA: Therapeutics and Global Markets Report. Report Synopsis mRNA Therapeutics Markets Segmentation Analysis Segmentation by Type of Drugs Within the domain of mRNA therapeutics, two key categories emerge: prophylactic vaccines and therapeutic drugs. Prophylactic vaccines are pivotal in preventing specific diseases, leveraging the mRNA platform's agility for rapid development and adaptation, notably showcased by the success of mRNA-based COVID-19 vaccines like Pfizer-BioNTech and Moderna. These vaccines hold promise for addressing emerging infectious diseases swiftly. On the other hand, therapeutic drugs encompass a wide range of applications, from oncology to infectious diseases, genetic disorders, and autoimmune conditions. mRNA therapies offer tailored treatment options, including personalized cancer vaccines and targeted treatments for various ailments, capitalizing on the platform's versatility and efficacy. Regional Focus Areas Segmentation Different regions exhibit varying degrees of involvement and investment in mRNA therapeutics. North America stands as a prominent hub for research and development, benefitting from significant investments, robust clinical trial infrastructure, and favorable regulatory environments. Europe follows suit with collaborative efforts and increasing adoption of mRNA-based treatments. The Asia-Pacific region showcases growing interest and investment, particularly in countries like China and India, while the Middle East and Africa demonstrate emerging awareness and potential for market growth. South America is witnessing a rise in awareness and participation in mRNA clinical trials, indicating untapped market potential and opportunities for growth in the region. International collaborations play a crucial role across all regions, driving research and development efforts and shaping the future landscape of mRNA therapeutics. This report on mRNA Therapeutics and Global Markets provides comprehensive insights and analysis, addressing the following key questions: What is the projected market size and growth rate of the market? The mRNA therapeutics market is valued at $60 billion and it is growing at -8.6% during the forecasting period to reach $21 billion. What are the key factors driving the growth of the market? The key factors driving the growth are the increasing investment in the mRNA technology and the rise in pandemic and epidemics. What segments are covered in the market? The mRNA market has been studied by type and by region. By Application, which segment will dominate the market by the end of 2028? The COVID vaccine will decline yet still dominate the market, as it will become part of regular vaccination regime in developed countries. Which region has the highest market share in the market? North America holds the highest share in the market. Some of the Key Market Players Are: ARCTUR U.S. THERAPEUTICS INC. CUREVAC N.V. MERCK KGAA NUTCRACKER THERAPEUTICS STRAND THERAPEUTICS BIONTECH SE GENNOVA BIOPHARMACEUTICALS LTD. MODERNA INC. OMEGA THERAPEUTICS INC. VAXESS TECHNOLOGIES INC. Browse Related Reports: RNAi Drug Delivery: Technologies and Global Markets : This research report provides a comprehensive categorization of the nucleic acid drugs market, primarily focusing on two major product segments: conjugated and encapsulated nucleic acid drugs. Encapsulated drugs are further delineated by the types of non-viral vectors employed, including polymers, lipids, and other materials like inorganic substances and hybrid systems. Moreover, segmentation extends across molecule types, delivery modes, and therapeutic areas, distinguishing between therapeutic and research-based applications. Geographically, the market analysis spans North America, Europe, the Asia-Pacific region, and the Rest of the World (RoW), offering insights into regional trends and dynamics within the nucleic acid drugs industry. Directly Purchase a copy of the report with BCC Research. For further information or to make a purchase, please get in touch with [email protected]. About BCC Research BCC Research provides objective, unbiased measurement and assessment of market opportunities with detailed market research reports. Our experienced industry analysts' goal is to help you make informed business decisions, free of noise and hype. Contact Us Corporate HQ: 50 Milk St. Ste 16, Boston, MA 02109, USA Email: [email protected], Phone: +1 781-489-7301 For media inquiries, email [email protected] or visit our media page for access to our market research library. Data and analysis extracted from this press release must be accompanied by a statement identifying BCC Research LLC as the source and publisher. Logo: SOURCE BCC Research LLC

Less than a week after announcing that regulators have greenlit the first tests of its tumor-busting mRNA therapy, Strand Therapeutics has laid off roughly 18% of its employees, Endpoints News has learned. Strand was founded in 2017 based on research of MIT synthetic biologists who figured out how to program on and off switches into mRNA. Those genetic circuits, as they’re called, offered a way to potentially improve the safety and effectiveness of drugs based on the genetic molecules. You’ll get access to free articles each month, plus you can customize what newsletters get delivered to your inbox each week, including breaking news.