Symic Bio, Inc.

DUBLIN, March 1, 2024 /PRNewswire/ -- The "Peripheral Arterial Disease (PAD) Therapeutics: Global Strategic Business Report" report has been added to ResearchAndMarkets.com's offering. Global Peripheral Arterial Disease (PAD) Therapeutics Market to Reach $7 Billion by 2030 The global market for Peripheral Arterial Disease (PAD) Therapeutics estimated at US$4 Billion in the year 2022, is projected to reach a revised size of US$7 Billion by 2030, growing at a CAGR of 7.1% over the analysis period 2022-2030. Peripheral Stents, one of the segments analyzed in the report, is projected to record a 6.9% CAGR and reach US$1.7 Billion by the end of the analysis period. Taking into account the ongoing post pandemic recovery, growth in the Peripheral Angioplasty Balloons segment is readjusted to a revised 6.4% CAGR for the next 8-year period. The U.S. Market is Estimated at $1.2 Billion, While China is Forecast to Grow at 6.7% CAGR The Peripheral Arterial Disease (PAD) Therapeutics market in the U.S. is estimated at US$1.2 Billion in the year 2022. China, the world's second largest economy, is forecast to reach a projected market size of US$1.2 Billion by the year 2030 trailing a CAGR of 6.7% over the analysis period 2022 to 2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 6.3% and 5.9% respectively over the 2022-2030 period. Within Europe, Germany is forecast to grow at approximately 5.5% CAGR. MARKET OVERVIEW Influencer Market Insights World Market Trajectories PAD - A Prelude Recent Market Activity PAD Statistics Critical Limb Ischemia - An Insight High Costs - A Cause of Concern Peripheral Arterial Disease (PAD) Therapeutics - Global Key Competitors Percentage Market Share in 2022 (E) Impact of Covid-19 and a Looming Global Recession Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2022 (E) MARKET TRENDS & DRIVERS Aging - A Key Driver High Diabetes Incidence Worldwide: Key Market Opportunity for PAD Therapeutics FOCUS ON SELECT PLAYERS (Total 32 Featured) AstraZeneca Plc. (UK) Bayer HealthCare Pharmaceuticals (Germany) Bristol-Myers Squibb Company (US) Merck & Co., Inc. (US) Proteon Therapeutics, Inc. (US) Sanofi S.A. (France) Symic Bio, Inc. (US) TheraVasc Inc. (US) For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

Dublin, Dec. 31, 2020 (GLOBE NEWSWIRE) -- The "Chronic Kidney Disease (CKD) - Pipeline Insight, 2020" drug pipelines has been added to ResearchAndMarkets.com's offering. The "Chronic Kidney Disease (CKD) - Pipeline Insight, 2020," report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in Chronic Kidney Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Chronic Kidney Disease Emerging Drugs Chapters This segment of the Chronic Kidney Disease report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases. Chronic Kidney Disease Emerging Drugs AZD5718: AstraZeneca AstraZeneca is conducting a study to evaluate the dose-response efficacy, safety, and pharmacokinetics (PK) of AZD5718 in participants with proteinuric chronic kidney disease. The study will be conducted in approximately 118 study centers across 12 countries. The overall study period will be around 28 weeks. Approximately 632 participants comprising of 67% diabetic kidney disease (DKD) and 33% non-DKD participants will be enrolled. DDO-3055: Jiangsu HengRui Medicine Co., Ltd. Jiangsu HengRui Medicine is conducting a randomized, double-blind, dose-escalating, placebo controlled, phase I study to evaluate the safety and pharmacokinetics and pharmacodynamics of DDO-3055 in healthy volunteers and patients with Chronic Kidney Disease. This is a randomized, double-blind, dose-escalating, placebo controlled, Phase I study to evaluate the safety, pharmacokinetics and pharmacodynamics of DDO-3055 in healthy volunteers and patients with chronic kidney disease. 48 healthy volunteers will be enrolled in Part A, and 18 patients with chronic kidney disease will be enrolled in Part B. Chronic Kidney Disease: Therapeutic Assessment This segment of the report provides insights about the different Chronic Kidney Disease drugs segregated based on following parameters that define the scope of the report, such as: Major Players in Chronic Kidney Disease There are approx. 50+ key companies which are developing the therapies for Chronic Kidney Disease. The companies which have their Chronic Kidney Disease drug candidates in the mid to advanced stage, i.e. phase III and Phase II include, AstraZeneca, UnicoCell Biomed, Jiangsu Hansoh Pharmaceutical, Bio Sidus, Keryx Biopharmaceuticals, AMAG Pharmaceuticals, inRegen, AbbVie etc. Phases The report covers around 50+ products under different phases of clinical development like Mid-stage products (Phase II and Phase I/II) Early-stage products (Phase I/II and Phase I) along with the details of Pre-clinical and Discovery stage candidates Discontinued & Inactive candidates Route of Administration Chronic Kidney Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as Subcutaneous Intravenous Oral Intramuscular Molecule Type Products have been categorized under various Molecule types such as Small molecules Proteins and peptides Polymers Diamines Chlorinated hydrocarbons Product Type Drugs have been categorized under various product types like Mono, Combination and Mono/Combination. Chronic Kidney Disease: Pipeline Development Activities The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Chronic Kidney Disease therapeutic drugs key players involved in developing key drugs. Pipeline Development Activities The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Chronic Kidney Disease drugs. Report Highlights The companies and academics are working to assess challenges and seek opportunities that could influence Chronic Kidney Disease R&D. The therapies under development are focused on novel approaches to treat/improve Chronic Kidney Disease. August 2020: DAPA-CKD trial meets primary endpoint in patients with chronic kidney disease. Dapagliflozin reduces the risk of kidney failure, death from cardiovascular causes or heart failure hospitalisation and all-cause mortality in chronic kidney disease patients with or without type 2 diabetes. That's the main result of the DAPA-CKD trial presented in a Hot Line session today at ESC Congress 2020. Chronic Kidney Disease Report Insights Chronic Kidney Disease Pipeline Analysis Therapeutic Assessment Unmet Needs Impact of Drugs Chronic Kidney Disease Report Assessment Pipeline Product Profiles Therapeutic Assessment Pipeline Assessment Inactive drugs assessment Unmet Needs Key Questions Current Treatment Scenario and Emerging Therapies: How many companies are developing Chronic Kidney Disease drugs? How many Chronic Kidney Disease drugs are developed by each company? How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Chronic Kidney Disease? What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Chronic Kidney Disease therapeutics? What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies? What are the clinical studies going on for Chronic Kidney Disease and their status? What are the key designations that have been granted to the emerging drugs? Key Players AdAlta Ltd Allena Pharmaceuticals Inc apceth Biopharma GmbH Arch Biopartners Inc Astellas Pharma Inc AstraZeneca Plc Bayer AG BiOrion Technologies BV Boehringer Ingelheim GmbH Boryung Pharmaceutical Co Ltd Celgene Corp Certa Therapeutics Pty Ltd Conatus Pharmaceuticals Inc Corvidia Therapeutics Inc DiaMedica Therapeutics Inc Dimerix Bioscience Pty Ltd DiscoveryBiomed Inc DURECT Corp Epigen Biosciences Inc Galectin Therapeutics Inc GenKyoTex SA GNI Group Ltd iBio Inc IC-MedTech Inc Ipsen SA Isarna Therapeutics GmbH KBP BioSciences Co Ltd Kidney Fibrosis Klotho Therapeutics Inc Les Laboratoires Servier SAS ManRos Therapeutics Mironid Ltd NovaTarg Therapeutics Inc Novo Nordisk AS OPKO Health Inc Opsidio LLC Otsuka Holdings Co Ltd Pharmaxis Ltd Q BioMed Inc Redx Pharma Plc Regulus Therapeutics Inc Resverlogix Corp Sanwa Kagaku Kenkyusho Co Ltd Sarfez Pharmaceuticals Inc Scholar Rock Inc Sirnaomics Inc Sphaera Pharma Pte Ltd Symic Biomedical Inc Taisho Pharmaceutical Holdings Co Ltd Theravance Biopharma Inc Unity Biotechnology Inc Vascular Biogenics Ltd Vascular BioSciences VESSL Therapeutics Ltd Vicore Pharma AB Key Products AZD5718 MEDI8367 efepoetin alfa Verinurad Empagliflozin DDO-3055 KBP-5074 Doxercalciferol TRC101 Pegol-Sihematide For more information about this drug pipelines report visit Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research. CONTACT: ResearchAndMarkets.com Laura Wood, Senior Press Manager press@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

- MODIFY2 study evaluated safety and efficacy in pain management for patients with mild-to-moderate osteoarthritis of the knee - [07-February-2018] SAN FRANCISCO, Feb. 7, 2018 /PRNewswire/ -- Symic Bio, a biopharmaceutical company developing novel extracellular matrix targeting drugs, today announced topline results from the MODIFY2 Phase 2 clinical trial of SB-061 for symptom management in mild-to-moderate osteoarthritis of the knee. The 12-week, multicenter, double-blind trial of 60 patients was designed to investigate the effects of SB-061 in the overall population as well as a prespecified subpopulation of patients with knee effusions. MODIFY2 demonstrated that treatment with SB-061 was well-tolerated, with a safety pro with the saline control treatment group. In patients with knee effusions, measurements of reduction in pain from baseline at 4 weeks by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain while walking score (WOMAC A1), were consistent with SB-061 treatment providing a clinically relevant degree of improvement compared to the control group, although these observations did not reach the threshold of statistical significance as the trial was designed with a small sample size. In patients with knee effusions, the repeated measures analysis of pain reduction over 4 weeks and repeated measures analysis of pain reduction over 12 weeks were consistent with an effect of SB-061 in potentially providing a clinically meaningful degree of improvement relative to control. These observations of a potential treatment effect were maintained in the WOMAC pain and function sub-scores as well as the full WOMAC. In the overall patient population including patients with and without effusions, treatment with SB-061 did not meet the primary endpoint of demonstrating a clinically meaningful improvement compared to control. "We are encouraged by the performance of SB-061 in the clinic thus far, especially the data in patients with effusions," said Nathan Bachtell, M.D., Chief Medical Officer of Symic Bio. "These results build upon previously announced Phase 1/2a results from the MODIFY-OA trial that supported the safety, tolerability and intended mechanism of action of SB-061. Given the biomarker results and efficacy signal seen in subjects with knee effusions in the MODIFY-OA trial, a specific cohort from this patient population which is known to have more active inflammation in the joint, the MODIFY2 trial was designated a priori to analyze this patient subset. The MODIFY2 results support that patients with effusions have a clinically meaningful response to SB-061 that can be confirmed in a study focused on patients in this population. We expect to provide additional detail at an upcoming medical conference." "Targeting a subset of osteoarthritis patients with active inflammation, as evidenced by the presence of an effusion, together with the multifaceted anti-inflammatory properties SB-061, reflects the coming trend in osteoarthritis development given the heterogenicity in the osteoarthritis population," commented Ali Guermazi, M.D., Ph.D., Professor of Musculoskeletal Radiology and Vice Chair of Academic Affairs at Boston University School of Medicine. "Given the signal in the MODIFY2 trial, targeting a subpopulation with effusions reflects a personalized approach to successful clinical development." "Ongoing development of SB-061 as an agent that can modify both the symptoms and disease progression of osteoarthritis will focus on patients with knee effusions, which constitutes more than 50 percent of those diagnosed with osteoarthritis of the knee," commented Ken Horne, Chief Executive Officer of Symic Bio. "Targeting patients with active synovial inflammation represents a novel approach to enriching a trial population, a strategy that we expect to contribute to effective clinical development. We are currently planning a Phase 2b trial of SB-061 for these patients, which we expect to initiate this year." Additional information on the design of SB-061 for the treatment of osteoarthritis can be found at . SB-061 from Symic Bio Osteoarthritis is a chronic inflammatory disease effecting approximately 10 percent of the U.S. population.1 Of these patients, approximately 50 percent have evidence of an accumulation of fluid in the affected joint, known as an effusion, as a result of active inflammation.2 SB-061, a therapeutic bioconjugate molecule inspired by the properties of aggrecan, is a drug delivered directly to the joint via intra-articular injection. SB-061 is designed to directly target the extracellular matrix within the joint cavity and inhibit degradation, halting the matrix-induced inflammatory cycle that drives the symptoms and progression of osteoarthritis. The goal of this approach is to both modify the course of disease by reducing joint degradation and to decrease symptoms due to inflammation. SB-061 is in clinical development for patients with osteoarthritis of the knee with effusions. 1. Murphy L., and Helmick, C.G. American Journal of Nursing. 2012 March;112(3 Suppl 1):S13-9 2. Maricar, N. et al., Seminars in Arthritis & Rheumatism. 2016 April;45(5):556-63. About Symic Bio Symic Bio is a biopharmaceutical company developing novel matrix regulators, a new category of therapeutics focused on matrix biology. These therapeutics, with potential applications in a wide variety of disease states, are inspired by naturally occurring macromolecules that play key regulatory roles within the extracellular matrix. Symic Bio currently has two clinical candidates: SB-061, directed at disease modification and pain management in the treatment of osteoarthritis, and SB-030, targeting the prevention of peripheral vein graft failure. In addition, Symic Bio is investigating applications in the areas of fibrosis, oncology and diseases of the central nervous system. For additional information please visit the company's website at , LinkedIn page at or follow on Twitter at .