Guizhou Tian'an Pharmaceutical Co. Ltd.

Primary objective: To compare the differences in absorption degree and absorption rate between pioglitazone hydrochloride dispersible tablets (specification: 30 mg) provided by Guizhou Tianan Pharmaceutical Co., Ltd. and pioglitazone hydrochloride tablets (trade name: ACTOS®, specification: 30 mg) certified by Takeda Teba Pharmaceutical Co., Ltd. in healthy Chinese population under fasting and postprandial administration conditions using a single-center, randomized, open, two-dose, two-period crossover, single-dose, fasting and postprandial administration design. Secondary objective: To evaluate the safety of pioglitazone hydrochloride dispersible tablets (specification: 30 mg) provided by Guizhou Tianan Pharmaceutical Co., Ltd. and pioglitazone hydrochloride tablets (trade name: ACTOS®, specification: 30 mg) certified by Takeda Teba Pharmaceutical Co., Ltd. under fasting and postprandial conditions.

A single-center, randomized, open, two-period, self-crossover, single-dose design was used to compare the differences in absorption extent and rate between calcium dobesilate capsules (specification: 0.5 g) produced by Guizhou Tianan Pharmaceutical Co., Ltd. and calcium dobesilate capsules (trade name: Doxium®/Doxium®, specification: 0.5 g) produced by Ebewe Pharma Ges.m.b.H.Nfg.KG in healthy Chinese people under fasting and postprandial administration conditions, and to evaluate the safety of calcium dobesilate capsules produced by Guizhou Tianan Pharmaceutical Co., Ltd.

Preliminary test: determine the dosage of the formal test; explore the intra-individual variability of the drug to provide a basis for the sample size calculation of the formal test. Formal test: use acarbose tablets produced by Guizhou Tianan Pharmaceutical Co., Ltd. as the test preparation and acarbose tablets produced by Bayer Healthcare Co., Ltd. (Beijing, China) as the reference preparation to evaluate the bioequivalence between the two preparations and observe the safety of the test preparation and the reference preparation in healthy subjects.