Zhejiang China Resources Sanjiu Zhongyi Pharmaceutical

Primary objective: To compare the differences in absorption degree and speed of desloratadine tablets (specification: 5 mg) provided by Zhejiang China Resources Sanjiu Zhongyi Pharmaceutical Co., Ltd. and desloratadine tablets (specification: 5 mg, trade name: Enlisi®) certified by N.V. Organon in healthy people under fasting and postprandial administration conditions. Secondary objective: To evaluate the safety of desloratadine tablets (specification: 5 mg) provided by Zhejiang China Resources Sanjiu Zhongyi Pharmaceutical Co., Ltd. and desloratadine tablets (specification: 5 mg, trade name: Enlisi®) certified by N.V. Organon under fasting and postprandial conditions.

To study the relative bioavailability of a single oral dose of entecavir capsules produced by Zhejiang Lishui Zhongyi Pharmaceutical Co., Ltd. and entecavir tablets (Boluding?) produced by Shanghai Bristol-Myers Squibb Pharmaceuticals Co., Ltd. in healthy male subjects, and to evaluate the bioequivalence of the test preparation of entecavir capsules and the reference preparation of entecavir tablets (Boluding?).

Main purpose: Using pharmacokinetic parameters as the primary endpoint evaluation indicators, the pharmacokinetic behavior of the test preparation calcitriol soft capsule (licensed by Zhejiang Huarun Sanjiu Zhongyi Pharmaceutical Co., Ltd.) and the reference preparation calcitriol capsule (licensed by Roche Pharma (Schweiz) AG, trade name: Rogaquan®) in healthy subjects after oral administration in the fasting/postprandial state was compared to evaluate the bioequivalence of the two preparations. Secondary purpose: Observe the safety of the test preparation calcitriol soft capsule and the reference preparation calcitriol capsule in healthy subjects.