Beijing Jiashi Daheng Pharmaceutical Co. Ltd.

Primary objective: Using arginine ibuprofen tablets (0.4 g (in terms of ibuprofen)) produced by Beijing Chengji Pharmaceutical Co., Ltd. as the test preparation, and in accordance with the relevant provisions of the bioequivalence test, arginine ibuprofen tablets (trade name: Spathox, specification: 0.4 g (in terms of ibuprofen)) held by Hainan Zanbang Pharmaceutical Co., Ltd. were used as the reference preparation for a bioequivalence test to compare the bioequivalence of the two preparations after a single dose under postprandial conditions. Secondary objective: Evaluate the safety of a single oral dose of the test preparation (arginine ibuprofen tablets, T) and the reference preparation (Spathox, R) in healthy adult subjects in China.

Main purpose: Using pharmacokinetic parameters as the primary endpoint evaluation indicators, the pharmacokinetic behavior of the test preparation minocycline hydrochloride capsules (specification: 100 mg, licensee: Beijing Chengji Pharmaceutical Co., Ltd.) and the reference preparation minocycline hydrochloride capsules (specification: 100 mg, licensee: Pfizer Japan Inc., trade name: MINOMYCIN®) in healthy subjects after oral administration in the fasting/postprandial state was compared to evaluate the bioequivalence of the two preparations. Secondary purpose: Observe the safety of the test preparation minocycline hydrochloride capsules and the reference preparation minocycline hydrochloride capsules in healthy subjects.

Primary objective: Using arginine ibuprofen tablets (0.4 g (in terms of ibuprofen)) produced by Beijing Chengji Pharmaceutical Co., Ltd. as the test preparation, and in accordance with the relevant provisions of the bioequivalence test, arginine ibuprofen tablets (trade name: Spathox, specification: 0.4 g (in terms of ibuprofen)) held by Hainan Zanbang Pharmaceutical Co., Ltd. were used as the reference preparation for a bioequivalence test to compare the bioequivalence of the two preparations under fasting and postprandial conditions. Secondary objective: Evaluate the safety of a single oral dose of the test preparation (arginine ibuprofen tablets, T) and the reference preparation (Spathox, R) in healthy adult subjects in China.