Article
Author: Edgerly, Yvonne M ; Thumbigere-Math, Vivek ; Lowry, Christopher A ; Groer, Maureen E ; Brenner, Lisa A ; Constantine, Niel T ; Hsu, Kuei-Ling ; Achtyes, Eric ; Joseph, Joshua ; Dagdag, Aline ; Hoisington, Andrew J ; Leach, Richard ; Ernst, Robert K ; Postolache, Teodor T ; Wadhawan, Abhishek ; Sha, Qiong ; Schifferle, Robert E ; Reynolds, Mark A ; Volkov, Janna ; Brundin, Lena
BACKGROUND:Periodontal disease (PD) is a common oral infection that is often exacerbated during pregnancy. Porphyromonas gingivalis (P. gingivalis), a keystone PD pathogen, promotes systemic inflammation, depressive-like behavior in animals, and can translocate to the brain and genital tract. Its capsular antigens (K1-K7) are key virulence factors. We hypothesized that seropositivity to specific P. gingivalis capsular K serotypes is associated with depressive symptoms and systemic inflammation during pregnancy.
METHODS:In a prospective cohort of pregnant women (N = 114), depressive symptoms were assessed in each trimester of pregnancy using the Edinburgh Postnatal Depression Rating Scale (EPDS, ≥13 denoting moderate-to-severe depression symptoms). Plasma IgG antibodies against P. gingivalis K1-K7 serotypes and proinflammatory cytokines were measured. Statistical analyses included Firth's bias-reduced logistic regression and mixed-effects linear models.
RESULTS:Approximately 25 % of participants were seropositive for at least one K serotype. IgG seropositivity to P. gingivalis K1 serotype was significantly associated with moderate-to-severe depressive symptoms during the first trimester (EPDS≥13; P = 0.035). Additionally, aggregated K seropositivity was significantly associated with elevated plasma IL-10 levels during the first trimester (P < 0.05, adjusted for multiple comparisons). Other cytokines were unrelated to P. gingivalis K seropositivity.
LIMITATIONS:We did not assess clinical or radiological manifestations of PD, antibodies to non-capsular P. gingivalis antigens, or the presence of other PD pathogens.
CONCLUSION:These results suggest the importance of integrating IgG K seropositivity (which, in addition to local oral pathogens, may also reflect their distal translocation) with clinical, bacteriological and radiological measures when studying associations between PD and affective dysregulation in pregnancy.