Delving into the Latest Updates on Shanghai Qingsai Biotechnology Co., Ltd. with Synapse

Overview

Tags

Infectious Diseases

Other Diseases

Respiratory Diseases

Prophylactic vaccine

Vaccine

Live attenuated vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	4

Top 5 Drug Type	Count

Prophylactic vaccine	3
Vaccine	1
Biosimilar	1
Live attenuated vaccine	1

Top 5 Target	Count

SARS-CoV-2 S protein	1

Mumps virus (MuV) is highly neurotropic and neurovirulent, hence, the neurovirulence of virus seeds used in the production of mumps vaccines must be tested. The previous neurovirulence evaluation method involves measuring the area of the cavity in the Lewis neonatal rat brain caused by MuV through paraffin sectioning and hematoxylin-eosin (HE) staining. However, the processes of paraffin sectioning and HE staining are time consuming and complicated. To solve this problem, in this study, a vibratome sectioning system was first deployed to evaluate MuV neurovirulence in the rat brain instead of paraffin sectioning and HE staining. The results showed that the vibratome sectioning method could assess the neurovirulence potential of MuV more objectively and efficiently. In addition, the effects of different MuV doses and the ages of the rats in days on this evaluation method were explored. The results indicate that MuV at no less than 10 50 % cell culture infective dose (CCID₅₀) could cause obvious cavity formation in 1-day-old rat brains. The neonatal rat model developed in this study could evaluate the neurovirulence of different MuV strains with high sensitivity and good repeatability.

01 Apr 2021·Virologica Sinica

A Highly Attenuated Mumps Virus Strain of Genotype F Generated by Passaging in Vero Cells.

Letter

Author: Chai, Benjie ; Zhang, Yajing ; Ruan, Juncheng ; Tian, Dayong ; Xie, Lixia ; Fu, Zhenfang ; Niu, Biao ; An, Qi ; Zhang, Yachun ; Gu, Yulin

01 Jun 2020·Virologica Sinica

Isolation and Growth Characteristics of SARS-CoV-2 in Vero Cell

Letter

Author: Wang, Hui ; Su, Bo ; Tian, Dayong ; Gu, Yulin ; Chen, Lei ; Sun, Yisheng ; Zhu, Hanping ; Zhang, Yajing ; Chen, Chen ; Wang, Dehui ; Chen, Jiancai ; Zhu, Zhiyong ; Xu, Fang ; Xie, Lixia ; Ruan, Juncheng ; Zhang, Yachun ; Guo, Yue ; Fu, Zhenfang ; Yang, Zhangnv ; Zhao, Yuying ; An, Qi ; Niu, Biao ; Jiang, Jianmin ; Yao, Pingping ; Lu, Hangjing

Here we report the isolation and characterization ofseven isolates of SARS-CoV-2 from seven patients.All these isolates were adapted to grow in Vero cells, and showed significant different replication characteristics.Sequence anal. revealed that these viruses sharedsimilar sequences to reported SARS-CoV-2 strains, except for 8#.

100 Deals associated with Shanghai Qingsai Biotechnology Co., Ltd.

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100 Translational Medicine associated with Shanghai Qingsai Biotechnology Co., Ltd.

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Pipeline

Pipeline Snapshot as of 15 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Phase 2 Clinical

Phase 3 Clinical

1

NDA/BLA

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Human rabies vaccine(chicken embryo fibroblasts)(Beijing Cell-fusion)	Rabies More	NDA/BLA
Rabies Vaccine(Jiangxi Qingfeng Pharmaceutical)	Rabies More	Phase 3
Mumps Vaccine, Live, Recombinant(F genotype)(Shanghai King-cell)	Mumps More	Phase 2
CoVac501 ( SARS-CoV-2 S protein )	COVID-19 More	Preclinical
Measles mumps rubella combined live attenuated vaccine(Beijing Cell-fusion Biotechnology Co. Ltd.)	Mumps More	Unknown