Mechanism and efficacy prediction indicators Following Repetitive Transcranial Magnetic Stimulation in Children With ASD:Functional magnetic resonance imaging study

Start Date22 Sep 2024

Sponsor / Collaborator

Children's Hospital of Nanjing Medical University

ChiCTR2400088204 / SuspendedPhase 4IIT

Development of a growth hormone treatment prognostic model for short stature children: a multicenter cohort study of short stature children

Start Date01 Sep 2024

Sponsor / Collaborator

Children's Hospital of Nanjing Medical University

ChiCTR2400087195 / SuspendedNot ApplicableIIT

Effect of stepwise nonpharmacological intervention for procedural pain on neuropsychological development and physical growth of preterm infants.

Start Date22 Jul 2024

Sponsor / Collaborator

Children's Hospital of Nanjing Medical University

100 Clinical Results associated with Children's Hospital of Nanjing Medical University

0 Patents (Medical) associated with Children's Hospital of Nanjing Medical University

552

Literatures (Medical) associated with Children's Hospital of Nanjing Medical University

31 Dec 2024·Human Vaccines & Immunotherapeutics

The seroepidemiology of immunoglobulin G antibodies against pertussis toxin and filamentous hemagglutinin in the east of China during the COVID-19 pandemic

Article

Author: Sun, Xiang ; Zhou, Juan ; Wu, Yun ; Wang, Wen ; Zhang, Tingting ; Xu, Yan ; Sun, Jinning ; Chen, Qiang ; Jia, Chengmei ; Wang, Zhiguo

This study employed sero-epidemiological methods to estimate the incidence of pertussis within a healthy population located in eastern China. The aim was to gain deeper insights into the epidemiological characteristics and burden of pertussis within the country. Blood samples were collected from healthy individuals in Jiangsu Province between June 2019 and December 2022. The levels of IgG antibodies against pertussis toxin (anti-PT) and filamentous hemagglutinin (anti-FHA) in the serum were quantitatively measured using enzyme-linked immunosorbent assay (ELISA). Additionally, pertussis case data reported in Jiangsu Province were collected from the China Information System for Disease Control and Prevention and compared with the results of this study. In 2022, the reported incidence of pertussis stood at 1.0 per 100,000 individuals, marking the highest rate observed in the past two decades. Among 1,909 patients examined, the geometric mean concentration (GMC) of anti-PT IgG antibody was 20.2 (18.5-21.9) IU/ml, while that of anti-FHA IgG antibody was 27.0 (25.4-28.7) IU/ml. The IgG-PT and IgG-FHA seropositivity rate (>20.0 IU/ml) was highest in the 1 ~ 2 y old group and decreased rapidly to the lowest in the 3 ~ 4 y old group and then increased gradually with age. The estimated rate of pertussis infection based on seroprevalence was approximately 25,625-fold higher than the reported notification rate in the ≥15 year age group. Our findings highlight decreased immunity post-vaccination, stressing the importance of additional booster shots for adolescents and adults to maintain immunity and reduce severe illness. Additionally, they offer vital guidance for policymakers to enhance immunization strategies.

01 Dec 2024·Colloids and Surfaces B: Biointerfaces

Biomimetic triggered release from hydroxyethyl cellulose @ Prussian blue microparticles for tri-modality biofilm removal

Article

Author: Muhire, Jules ; Xie, Min ; Qu, Qingli ; Zhang, Xiaoli ; Huang, Chaobo ; Pei, Dong ; Xiong, Ranhua ; Yang, Anquan ; Cheng, Weixia

Human health is under growing threat from the increasing incidence of bacterial infections. Through their antimicrobial mechanisms, bacteria use appropriate strategies to overcome the antimicrobial effects of antibiotics. The enhanced effects of synergistic strategies on drug-resistant bacteria and biofilms have led to increasing interest in these approaches in recent years. Herein, biomimetic hydroxyethyl cellulose @ Prussian blue microparticles (HEC@PB MPs) generated by the gas-shearing method show a synergistic antibacterial property induced by antibiotic-, photothermal- and photodynamic- effect. MPs, as tri-modality antibacterial agents, exhibit ideal antibacterial activity and biofilm removal effect, and their mode of action on bacteria was investigated. Additionally, a drug release concept encouraged by the ROS-driven breakdown of cellulose, as seen in brown-rot fungi, was introduced. It combines ROS-responsive HEC and photodynamic PB and is likely to fit a niche in many applications.

01 Dec 2024·Pediatric Cardiology

Perioperative Brain Injury in Children with Aortic Arch Anomalies: A Retrospective Study of Risk Factors and Outcomes

Article

Author: Qi, Jirong ; Ye, Mingtang ; Hu, Liang ; Mo, Xuming ; Peng, Wei ; Chen, Feng ; Wu, Kaihong ; Ding, Peicheng ; Ding, Jie ; Xu, Jiali

Complex pediatric cardiac disease is associated with brain impairment and neurodevelopmental disorders, particularly in patients requiring cardiac surgery for aortic arch anomalies. This study examines the incidence, risk factors, and outcomes of perioperative brain injury in children undergoing aortic arch repair who had aortic arch anomalies. A total of 145 children with aortic arch anomalies in our center undergoing aortic arch repair between January 2014 and December 2022 were enrolled. There were 129 (89.0%) with coarctation of the aorta (COA) and 16 (9.7%) with interrupted aortic arch (IAA). Risk factor analysis of brain injuries was done using perioperative imaging and included symptoms of hemorrhagic stroke, arterial ischemic stroke, white matter injury, cerebral sinus venous thrombosis, and other pathologies. Preoperatively, 50/145 (34.5%) patients had brain injuries. Multivariate analysis showed that an increased risk of hemorrhagic stroke was associated with newborns (odds ratio [OR], 2.09 [95% CI 0.08-3.50]), isolated COA (OR, 3.69 [95% CI 1.23-7.07]), mechanical ventilation (MV) ([OR, 2.56 [95% CI 1.25-4.03]), and sepsis (OR, 1.73 [95% CI 0.46-3.22]). Newborns ([OR, 1.91 [95% Cl 0.58-3.29]) and weight-for-age z score ([OR, -0.45 [95% CI -0.88 to -0.1]) were associated with an increased risk of white matter injury. New postoperative brain injuries were present in 12.9% of the patients (16/124). Deep hypothermic circulatory arrest (DHCA) was associated with new postoperative brain injuries compared with deep hypothermic low-flow (DHLF) plus antegrade cerebral perfusion (ACP) (([OR, 2.67 [95% CI, 0.58-5.75])). Isolated COA was almost associated with new postoperative brain injuries (OR, 1.13 [95% CI, -0.04 to 2.32]). Children diagnosed with isolated COA appeared to have a higher risk of perioperative brain injury, but the underlying mechanisms are still unclear. We focused on the intrinsic mechanism by which changes in hemodynamics caused by COA result in perioperative brain injury. Further research will be needed to optimize the personalized treatment and cerebral perfusion techniques for complex pediatric cardiac surgery.

100 Deals associated with Children's Hospital of Nanjing Medical University

100 Translational Medicine associated with Children's Hospital of Nanjing Medical University

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