China Gene PharmValley

Part A phase Main purpose: To evaluate the safety of hbFGF gel in the treatment of deep second-degree burns; To evaluate the preliminary effectiveness of hbFGF gel in the treatment of deep second-degree burns. Secondary purpose: To evaluate the pharmacokinetic (PK) characteristics of hbFGF gel after topical administration of hbFGF gel through the skin in patients with deep second-degree burns; To evaluate the immunogenicity of hbFGF gel after topical administration of hbFGF gel through the skin in patients with deep second-degree burns. Part B phase Main purpose: To evaluate the effectiveness of hbFGF gel in the treatment of deep second-degree burns and recommend appropriate doses for subsequent trials; To evaluate the safety of hbFGF gel in the treatment of deep second-degree burns. Secondary purpose: Based on the pharmacokinetic results of Part A, determine whether to evaluate the pharmacokinetic characteristics of hbFGF gel in Part B; Based on the immunogenicity results of Part A, determine whether to evaluate the immunogenicity of hbFGF gel in Part B.