A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of Anti-Stress Efficacy of Complementary-Alternative Medicine in Healthy subjects - A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study of Anti-Stress Efficacy of Complementary-Alternative Medicine in Healthy subjects

Start Date04 Jan 2021

Sponsor / Collaborator

Hyogo University of Health Sciences

100 Clinical Results associated with Hyogo University of Health Sciences

0 Patents (Medical) associated with Hyogo University of Health Sciences

791

Literatures (Medical) associated with Hyogo University of Health Sciences

02 Jul 2024·Physical Therapy

Prognosis of Pain After Stroke During Rehabilitation Depends on the Pain Quality

Article

Author: Tanaka, Yoichi ; Koga, Masayuki ; Sato, Gosuke ; Uragami, Shinji ; Igawa, Yuki ; Morioka, Shu ; Iki, Shinya ; Fuyuki, Masanori ; Sumitani, Masahiko ; Osumi, Michihiro

AbstractObjectivePain after a stroke interferes with daily life and the rehabilitation process. This study aimed to clarify the prognosis of pain in subgroups of patients with pain after a stroke using pain quality data.MethodsThe study included 85 patients with pain after stroke undergoing exercise-based rehabilitation. Items of the Neuropathic Pain Symptom Inventory (NPSI) were used, and patients with pain after stroke were clustered according to their scores of NPSI. Other clinical assessments, such as physical and psychological conditions, were assessed by interviews and questionnaires, and then these were compared among subgroups in a cross-sectional analysis. Longitudinal pain intensity in each subgroup was recorded during 12 weeks after the stroke and the patients’ pain prognoses were compared between subgroups.ResultsFour distinct subgroups were clustered: cluster 1 (cold-evoked pain and tingling), cluster 2 (tingling only), cluster 3 (pressure-evoked pain), and cluster 4 (deep muscle pain with a squeezing and pressure sensation). The cross-sectional analysis showed varying clinical symptoms among the subgroups, with differences in the prevalence of joint pain, limited range of motion, somatosensory dysfunction, and allodynia. There were no significant differences in pain intensity at baseline among the subgroups. A longitudinal analysis showed divergent prognoses of pain intensity among the subgroups. The pain intensity in cluster 4 was significantly alleviated, which suggested that musculoskeletal pain could be reduced with conventional exercise-based rehabilitation. However, the pain intensity of patients in clusters 1 and 2 remained over 12 weeks.ConclusionThe study classified patients into clinically meaningful subgroups using pain quality data and provided insight into their prognosis of pain. The findings could be useful for guiding personalized rehabilitation strategies for pain management.ImpactAssessment of pain quality in patients with pain after stroke leads to personalized rehabilitation for pain management.

01 Oct 2023·Journal of Affective Disorders

Relationship between circulating mitochondrial DNA and microRNA in patients with major depression

Article

Author: Koshikawa, Yosuke ; Kato, Tadafumi ; Kato, Masaki ; Tahara, Hidetoshi ; Kinoshita, Toshihiko ; Kageyama, Yuki ; Higasa, Koichiro ; Nonen, Shinpei ; Ogata, Haruhiko ; Shimamoto, Akira ; Takekita, Yoshiteru

BACKGROUNDMicroRNAs (miRNAs) and circulating cell-free mitochondrial DNA (ccf-mtDNA) have attracted interest as biological markers of affective disorders. In response to stress, it is known that miRNAs in mitochondria diffuse out of the cytoplasm alongside mtDNA; however, this process has not yet been identified. We hypothesized that miRNAs derived from specific cell nuclei cause mitochondrial damage and mtDNA fragmentation under MDD-associated stress conditions.METHODSA comprehensive analysis of the plasma miRNA levels and quantification of the plasma ccf-mtDNA copy number were performed in 69 patients with depression to determine correlations and identify genes and pathways interacting with miRNAs. The patients were randomly assigned to receive either selective serotonin reuptake inhibitors (SSRI) or mirtazapine. Their therapeutic efficacy over four weeks was evaluated in relation to miRNAs correlated with ccf-mtDNA copy number.RESULTSThe expression levels of the five miRNAs showed a significant positive correlation with the ccf-mtDNA copy number after correcting for multiple testing. These miRNAs are involved in gene expression related to thyroid hormone synthesis, the Hippo signaling pathway, vasopressin-regulated water reabsorption, and lysine degradation. Of these five miRNAs, miR-6068 and miR-4708-3p were significantly associated with the SSRI and mirtazapine treatment outcomes, respectively.LIMITATIONSThis study did not show comparison with a healthy group.CONCLUSIONSThe expression levels of specific miRNAs were associated with ccf-mtDNA copy number in untreated depressed patients; moreover, these miRNAs were linked to antidepressant treatment outcomes. These findings are expected to lead to the elucidation of new pathological mechanism of depression.

24 Jul 2023·Angewandte Chemie (International ed. in English)

Rotaxane Synthesis by an End-Capping Strategy via Swelling Axle-Phenols.

Article

Author: Yamaoka, Yousuke ; Kawabata, Takeo ; Takasu, Kiyosei ; Ueda, Yoshihiro ; Fujimura, Koki

A method for rotaxane synthesis by enlargement of the size of the terminal phenol group of the axle component by aromatic bromination has been developed. This method may be regarded as an end-capping strategy involving the swelling of the phenol group at the axle terminal. The advantages of the present strategy include: ready availability of axle components with a variety of swelling precursors, wide product scope (19 examples given including a [3]rotaxane), mild conditions for the swelling process, rich potential for the derivatization of the brominated rotaxanes, and possible release of the axle component by degradative dethreading of the thermally stable brominated rotaxanes under the basic conditions.

100 Deals associated with Hyogo University of Health Sciences

100 Translational Medicine associated with Hyogo University of Health Sciences

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