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Disease Domain	Count

Neoplasms	1

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Small molecule drug	1

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PDHK1 x PKM2	1

Photocatalysis has unprecedently prevailed in the removal of pollutants and the artificial photosynthesis of H₂O_2. However, inefficient surface reaction and exciton dissociation rate are the main hurdles in arriving at high photocatalytic performance.A versatile strategy for improving surface reactions between the photocatalyst and the reactant and the charge separation dynamics is in pressing need.Herein, post-quaternization of the conjugated microporous polymer (CMP) is proposed.This not only converts the CMP from hydrophobic to hydrophilic but also evidently improves charge separation and mobility due to the polarizing effect.Most importantly, because of the quaternization, the surface reactions can be pronouncedly strengthened due to both the improved dispersity and lowering of O₂ adsorption energy.As a result, the CMPs serve both photodegradation and photosynthesis of H₂O₂, with iB-TDZ exhibiting pronounced enhancement in the photodegradation of 100 ppm of Congo red and 2,4-D in 40 min and 90 min, resp., transcending the vast majority of the reported photocatalysts, while the production of H₂O₂ reaches 2.922 mmol g^-1 in three-hour irradiationAs a proof-of-concept experiment, simultaneous photodegradation of 2,4-D and photocatalytic H₂O₂ production is realized.It was found that 2,4-D can boost photocatalytic H₂O₂ production from 1.92 mmol g^-1 (without 2,4-D) to 3.25 mmol g^-1 within 90 min, likely due to its role in providing protons and serving as an h⁺ scavenger.These findings provide a fresh platform for the design of CMP-based photocatalysts for simultaneous photocatalytic wastewater treatment and H₂O₂ production

01 Jul 2025·Separation and Purification Technology

Recent advances in amino-functionalized metal–organic frameworks for sustainable photocatalytic carbon dioxide reduction

Author: Li, Tiantian ; Zhang, Jiye ; Qian, Junfeng ; Wang, Liang ; Guo, Huazhang ; Liu, Yaning ; Zhang, Zhihui ; Sun, Zhonghua

Recent advancements in photocatalytic CO₂ reduction have garnered significant interest, focusing on the harnessing of renewable solar energy to transform CO₂ into valuable chem. products.Metal-organic frameworks (MOFs) have emerged as promising candidates in this field due to their exceptional structural and photochem. properties as well as their remarkable CO₂ capture capabilities.Despite the growing attention, current photocatalysts face several limitations that hinder their widespread application.A compelling strategy to overcome these challenges involves the incorporation of amino groups into the MOF structure.This modification can significantly enhance the catalytic performance of MOFs under visible light by improving CO₂ reduction efficiency through several mechanisms.Specifically, amino functional groups boost the photocatalytic CO₂ capabilities through increasing light absorption, promoting the separation of charge carriers, and providing active sites, thereby improving efficiency, selectivity, and CO₂ adsorption capacity.This review presents the latest research advancements on amino-functionalized pristine MOFs, amino-functionalized MOFs composites, as well as their derivatives in photocatalytic CO₂ reductionIt discusses the unique advantages offered of amino-functionalized MOFs in this area and highlights their potential applications in future sustainable energy production and carbon capture technologies.The findings presented herein underscore the promising opportunities afforded by amino-functionalized MOFs in advancing photocatalytic CO₂ reduction efforts.

01 Jul 2025·Separation and Purification Technology

Synergistic effect of MIL-101(Cr) and nanoscale zero-valent iron (nZVI) for efficient removal of U(VI) and assessment of this composite to inactivate Escherichia coli

Author: Ma, Jianfeng ; Liang, Liping ; Komarneni, Sridhar ; Imanova, Gunel ; Xi, Fenfen ; Zhao, Jinhui

nZVI was immobilized on MIL-101(Cr), a metal-organic framework (MOF), and subsequently utilized for the removal of U(VI) from aqueous solutionThis composite was also tested for its toxicity to Escherichia coli (E. coli).The results demonstrated that MIL-101(Cr) and nZVI had a significant synergistic effect.This composite material is excellent for removing U(VI) and the optimal ratio of MIL-101(Cr) to nZVI was found to be 1.2:1 on mass basis.Adsorption data exhibited excellent fitting to the Freundlich and pseudo-second-order kinetic models, and a maximum removal capacity of 526.32 mg/g of U(VI) was achieved by M-Fe at 298 K (pH = 6.0).The removal mechanisms were clarified by the X-ray absorption near edge structure (XANES), XPS, and extended X-ray absorption fine structure (EXAFS).Results reveled that U(VI) was mainly removed through chemisorption, forming a bidentate mononuclear edge-sharing linkage between UO₃ pyramid and iron(hydro)oxide.Through free radical quenching experiments and EPR anal., it was indicated that the existence of reactive oxygen species (ROS) accelerates the oxidation of nZVI, generating more iron oxides or hydroxides for U(VI) adsorption, while inhibiting the reduction of U(VI) to U(IV).Furthermore, immobilized nZVI on MIL-101(Cr) mitigated the biotoxicity of Escherichia coli (E. coli).Direct contact played a crucial role in inactivating E. coli cells by nZVI/E. coli system.Extracellular reactive oxygen species (ROS) played a vital role in inactivating E. coli in the M-Fe/E. coli system where ^·OH is the main ROS.These findings enhance our understanding of the mechanism of U(VI) removal and bactericidal effect on organisms using ZVI-based composites, which will broaden the application scope of the two materials in pollution removal, especially in radioactive decontamination.

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100 Translational Medicine associated with Changzhou University

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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