The objective of this presentation is to overview recent developments in supercritical fluid processing technologies (SCF) for colloidal drug delivery systems and discuss formulation strategies for liposome, microemulsion, nanoparticle and dry powder inhalation systems using this technol.Supercritical fluid processing is a cutting-edge clean technol. that can be processed with active materials or a mixture of excipients and drugs.SCF processing has the potential to benefit the formulation of biomaterials including proteins, peptides and gene materials, as compared to the conventional methods of spray drying and lyophilization.Several SCF processes exist including rapid expansion of supercritical solutions (RESS), supercritical antisolvent (SAS) and gas antisolvent (GAS).Major considerations for particle formulation include the selection of the supercritical fluid process, solubility of excipients and active materials, solvent selection and particle stability.Particle size, particle morphol., and therapeutic drug activity are used to characterize the formulations.