Association of peripheral nerve block under general anesthesia on postoperative nausea and vomiting: a nationwide population-based study - Association of peripheral nerve block under general anesthesia on postoperative nausea and vomiting: a nationwide population-based study

Start Date28 Feb 2024

Sponsor / Collaborator

Ube Industries Central Hospital Corp.

JPRN-UMIN000039346

/ RecruitingNot Applicable

The incidence of phrenic nerve palsy after Clavipectoral fascial plane block - The incidence of phrenic nerve palsy after Clavipectoral fascial plane block

Start Date01 Jan 2020

Sponsor / Collaborator

Ube Industries Central Hospital Corp.

JPRN-UMIN000037866

/ CompletedNot Applicable

Examination of fascia illiac block area using thermography - Examination of fascia illiac block area using thermography

Start Date31 Aug 2019

Sponsor / Collaborator

Ube Industries Central Hospital Corp.

100 Clinical Results associated with Ube Industries Central Hospital Corp.

0 Patents (Medical) associated with Ube Industries Central Hospital Corp.

107

Literatures (Medical) associated with Ube Industries Central Hospital Corp.

01 Oct 2024·BMJ Case Reports

Ultrasound-guided spinal anaesthesia for a patient with severe scoliosis

Article

Author: Morimoto, Yasuhiro ; Yoshimura, Manabu

Ultrasound (US) guided spinal anaesthesia is gaining recognition for its ability to minimise technical difficulties encountered in patients with atypical spinal anatomy. Spinal anaesthesia is administered during a surgical procedure lithotripsy in patients with respiratory complications that can result from severe scoliosis or cerebral palsy. Here, we report a case in which US-guided spinal anaesthesia proved feasible and advantageous in a patient with cerebral paralysis and severe scoliosis. A man in his 60s with cerebral paralysis and severe scoliosis was scheduled for spinal anaesthesia because of his nocturnal SpO2 drops and need for nasal high flow. Using US guidance, we confirmed that the needle entry angle was consistent with the rotating spinous process. The spinal needle was then advanced successfully, and spinal anaesthesia was administered without issue. The US technique for detecting the rotation of the vertebrae and puncturing them is useful in patients with severe scoliosis.

01 Sep 2024·Journal of Clinical Anesthesia

Development and validation of a machine learning model to predict postoperative delirium using a nationwide database: A retrospective, observational study

Article

Author: Koga, Mami ; Shiramoto, Hiroko ; Morimoto, Yasuhiro ; Yoshimura, Manabu

STUDY OBJECTIVEPostoperative delirium is a neuropsychological syndrome that typically occurs in surgical patients. Its onset can lead to prolonged hospitalization as well as increased morbidity and mortality. Therefore, it is important to promptly identify its signs. This study aimed to develop and validate a machine learning predictive model for postoperative delirium using extensive population data.DESIGNRetrospective observational study.SETTINGJapanese Diagnosis Procedure Combination inpatient data. Data were used for internal (2016.4-2018.12) and temporal validation (2019.01-2019.10).PATIENTSPatients aged ≥65 years who underwent general anesthesia for surgical procedure.MEASUREMENTSThe primary outcome was postoperative delirium, which was defined as a condition requiring newly prescribed antipsychotic drugs or assignment of the corresponding insurance claim code after the date of surgery. We trained and tuned the optimal machine-learning model through 10-fold cross-validation using the selected optimal area under the receiver operating characteristic curve (AUC) value. In the temporal validation, we measured the performance of our model.MAIN RESULTSThe analysis included 557,990 patients. The light-gradient boosting machine models showed a higher AUC value (0.826 [95% confidence interval (CI): 0.822-0.829]) than the other models. Regarding performance, the model had a recall value of 0.124 (95% CI: 0.119-0.129) and precision value of 0.659 (95% CI: 0.641-0.677]). This performance was sustained in the temporal validation (AUC, 0.815 [95% CI: 0.811-0.818]). At a sensitivity of 0.80, the model achieved a specificity of 0.672 (95% CI: 0.670-0.674]), a negative predictive value of 0.975 (95% CI: 0.974-0.975), and a positive predictive value of 0.176 (95% CI: 0.176-0.179).CONCLUSIONSUsing extensive Diagnostic Procedure Combination data, we successfully created and validated a machine learning model for predicting postoperative delirium. This model may facilitate prediction of postoperative delirium.

01 Jul 2024·Pancreas

Multicenter Prospective Cohort Study of Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer (YPB-001)

Article

Author: Tokumitsu, Yukio ; Nishimura, Taku ; Hamano, Kimikazu ; Tanaka, Hidekazu ; Yahara, Noboru ; Ioka, Tatsuya ; Takami, Taro ; Nagano, Hiroaki ; Inokuchi, Toshihiro ; Matsui, Hiroto ; Harada, Eijiro ; Takahashi, Tsuyoshi ; Ito, Katsuyoshi ; Maeda, Yoshinari ; Kubo, Hidefumi ; Nakajima, Masao ; Shindo, Yoshitaro ; Kawaoka, Toru

ObjectivesThe present multicenter prospective observational study investigated the effectiveness and safety of neoadjuvant chemotherapy (NAC) for patients with borderline resectable pancreatic cancer (BRPC) and those with RPC contacting major vessels, with respect to a historical control of upfront surgery.Materials and MethodsPatients with BRPC and RPC contacting major vessels were prospectively registered and administered NAC with durations and regimens determined by the corresponding treating physician. Our primary aim was to assess the R0 resection rate, and secondary aim was to evaluate safety, resection rate, time to treatment failure, overall survival, and response rate.ResultsFifty of 52 enrolled patients were analyzed; 2 with serious comorbidities died during treatment. Thirty-one patients underwent resection, with R0 resection being achieved in 26 (52% of total and 84% of all resected cases). Univariate and multivariate analyses indicated age (≥75 years) as the only independent predictor of nonresection. Median progression-free survival and median survival time were longer in the prospective cohort than in the historical cohort.ConclusionsOverall, NAC for BRPC in real-world setting might yield R0 resection rates similar to those reported in previous clinical studies. Development of safe regimens and management strategies that can maintain treatment intensity in geriatric patients is warranted.

100 Deals associated with Ube Industries Central Hospital Corp.

100 Translational Medicine associated with Ube Industries Central Hospital Corp.

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