The goal of this clinical trial is to compare in patients undergoing thoracic procedures the lung inflammatory response in on one-lung ventilation and two-lung ventilation strategies The main question to answer is:
• Lung inflammation differs when comparing one to two-lung ventilation strategies during the procedure? Participants will be divided in the classic one lung ventilation or two lung ventilation (using pneumothorax with CO2) and different biomarkers of lung inflammation will be measured after procedures.

Start Date20 Jul 2023

Sponsor / Collaborator

Universidade do Extremo Sul Catarinense

100 Clinical Results associated with Universidade do Extremo Sul Catarinense

0 Patents (Medical) associated with Universidade do Extremo Sul Catarinense

3,261

Literatures (Medical) associated with Universidade do Extremo Sul Catarinense

01 Aug 2025·Journal of Tissue Viability

Atmospheric plasma control excessive inflammation and oxidative stress in burn wound healing in diabetes-induced rats

Article

Author: Pereira, Amanda Tavares ; Wiltler, Raul ; de Lima, Letícia ; de Sousa Mariano, Samara ; de Aro, Andrea Aparecida ; Lopes, Bruno Bellotti ; de Roch Casagrande, Laura ; Souza, Jennyffer ; Corezola do Amaral, Maria Esméria ; de Andrade, Thiago Antônio Moretti ; Bagne, Leonardo ; de Bem Silveira, Gustavo ; de Oliveira, Maraiara Aparecida ; Silveira, Paulo Cesar Lock

Burns are the fourth most prevalent trauma worldwide, and their complications are significantly exacerbated when associated with diabetes, leading to increased morbidity and mortality. This study addresses the urgent need for safe and effective treatments by exploring the therapeutic potential of atmospheric plasma (AP), an ionized gas produced at atmospheric pressure, in enhancing the healing of burn wounds. We investigated the effects of AP on the repair of second-degree dorsal burns in Wistar rats, induced to diabetes with alloxan (45 mg/kg). The animals were randomly assigned to either the sham group (plasma generator off) or the AP group (treated with AP for 1 min daily until the 2nd, 7th, 14th and 21st days). Our findings indicate that AP treatment significantly reduced inflammatory cell accumulation, increased interleukin levels, controlled oxidative damage, and stimulated antioxidant responses. Furthermore, AP promoted angiogenesis, fibroblast proliferation, and collagen fiber organization. These results suggest that AP accelerates tissue healing in diabetic burns, making it a promising treatment for improving burn wound healing in diabetes-induced conditions.

01 Jun 2025·The American Journal of Cardiology

Intravascular Imaging Improves Clinical Outcomes of Percutaneous Coronary Intervention for Chronic Total Occlusions: A Meta-Analysis of Randomized Controlled Trials

Review

Author: Ribeiro, Marcelo H ; Bueno, Ronaldo R L ; Viana, Patricia ; Carvalho, Pedro E P ; Costa, Ricardo A ; Nicz, Pedro F G ; Nercolini, Deborah C ; Lucena, Larissa A ; Falcão, Breno A A ; Gomes, Wilton F ; Zerlotto, Djinane S ; Quadros, Alexandre S

Clinical data comparing intravascular imaging (IVI)-guided percutaneous coronary intervention (PCI) with angiography-guided PCI for chronic total occlusions (CTOs) are limited. This study aimed to compare clinical outcomes of IVI-guided versus angiography-guided PCI in patients with CTOs. A systematic review and meta-analysis were conducted to identify randomized controlled trials (RCTs) comparing IVI-guided with angiography-guided PCI in CTO populations. The primary endpoint was the incidence of major adverse cardiac events (MACE), a composite of death/cardiac death, myocardial infarction (MI), and target-vessel revascularization (TVR). Secondary outcomes included the individual components of MACE. A prespecified subgroup analysis was performed for intravascular ultrasound (IVUS) and optical coherence tomography (OCT). Five RCTs, including 1,296 patients, were analyzed, with 713 (55%) undergoing IVI-guided PCI. Over 1 to 3 years, MACE was significantly lower in the IVI-guided PCI group (7.2% vs 13%; relative risk [RR] 0.55; 95% confidence interval [CI] 0.35 to 0.88; p = 0.012; I² = 31%). In the secondary analysis, TVR incidence was lower in the IVI group (3.1% vs 6.7%; RR 0.52; 95% CI 0.29 to 0.97; p = 0.038). No statistical differences were observed for MI or death/cardiac death. In the IVUS subgroup, MACE was also lower in the IVI-guided PCI group (8.4% vs 14.3%; RR 0.59; 95% CI 0.37 to 0.91; p = 0.019). A trial sequential analysis suggested a low likelihood of type I error. In conclusion, IVI-guided PCI is associated with improved clinical outcomes compared with angiography-guided PCI for the treatment of CTOs.

01 May 2025·Journal of Adolescent Health

Time Trends and Socioeconomic Inequalities in Parental Physical Aggression and Adolescent Physical Fighting: Three Brazilian Birth Cohort Studies Over Twenty Years, 2000–2020

Article

Author: Matijasevich, Alicia ; Murray, Joseph ; Gonçalves, Helen ; Santos, Ina S ; Barros, Aluisio J D ; Tovo-Rodrigues, Luciana ; Miranda, Vanessa Iribarrem Avena ; Coll, Carolina V N

PURPOSEViolence prevention requires robust data on trends in different forms of violence and measures of progress toward reduction across subgroups of the population. This study aimed to investigate trends and related socioeconomic inequalities in parental physical aggression and involvement in physical fights among adolescents.METHODSThree population-based birth cohorts were conducted, including all births in the calendar years 1982, 1993, and 2004 in Pelotas city, Southern Brazil, with over 4,200 births in each cohort. Confidential self-report questionnaires were used to measure parental physical aggression (ages 11 and 15 years) and involvement in physical fights (ages 11, 15, and 18). The prevalence of violence outcomes was estimated, stratifying by sex and family income group for each cohort, and income-related inequalities were assessed through time.RESULTSThere were significant reductions in parental physical aggression between cohorts, at ages 11 (prevalence ratio (PR): 0.83) and 15 years (PR: 0.70), and there was some evidence of reductions in income-related inequality regarding harsh parenting, mainly for boys. Considering physical fighting, there was a small increase through time for boys at age 11 (PR: 1.22), but no change for either sex at age 15, and declines for girls at age 18 years (PR: 0.50). There were income inequalities in physical fighting for girls at ages 11 and 15 (with a higher prevalence among the poorest adolescent girls in comparison to the richest), which persisted through time. However, income inequality in fighting among girls at age 18 reduced through time. There was little income inequality in fighting among boys at any age in any cohort.DISCUSSIONEncouraging declines in parental physical aggression have occurred over the past 2 decades in this population of adolescents, but there is less clear evidence of changes in physical fights. Continued monitoring is vital to inform violence prevention policies.

100 Deals associated with Universidade do Extremo Sul Catarinense

100 Translational Medicine associated with Universidade do Extremo Sul Catarinense

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 19 Jun 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Universidade do Extremo Sul Catarinense

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 19 Jun 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing