Wuhan Jiulong Renfu Pharmaceutical Co., Ltd.

Main purpose: To compare the absorption rate and extent of methylprednisolone tablets produced by Wuhan Jiulong Renfu Pharmaceutical Co., Ltd. with methylprednisolone tablets (trade name: Medrol®, reference preparation) produced by Pfizer Italia Srl in healthy human bodies according to the relevant provisions of bioequivalence test, and to investigate the bioequivalence of the two preparations in humans. Secondary purpose: To observe the safety of the test preparation methylprednisolone tablets and the reference preparation methylprednisolone tablets (Metrol®) in healthy subjects.

Primary objective: To investigate the pharmacokinetic characteristics of the test preparation estradiol valerate tablets (specification: 1 mg/tablet, produced by Wuhan Jiulong Renfu Pharmaceutical Co., Ltd.) and the reference preparation estradiol valerate tablets (Progynova®, specification: 1 mg/tablet; certified by Jenapharm GmbH & Co. KG) in healthy Chinese postmenopausal female participants after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations in the fasting and fed state. Secondary objective: To investigate the safety of the test preparation estradiol valerate tablets (specification: 1 mg/tablet) and the reference preparation estradiol valerate tablets (Progynova®, specification: 1 mg/tablet) in healthy Chinese postmenopausal female participants.

Primary objective: Using the ibuprofen suspension licensed by Wuhan Jiulong Pharmaceutical Co., Ltd. (produced by Wuhan Renfu Pharmaceutical Co., Ltd.) as the test preparation and the ibuprofen suspension (trade name: Meilin®) produced by Shanghai Johnson Pharmaceutical Co., Ltd. as the reference preparation, the pharmacokinetic parameters and relative bioavailability of the two preparations after a single administration in the fasting and postprandial state were investigated to evaluate whether the two preparations are bioequivalent. Secondary objective: To evaluate the safety of the ibuprofen suspension test preparation and reference preparation after a single oral administration in fasting/postprandial state in healthy Chinese subjects.