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A Phase I Trial of the MUC1 Inhibitor, GO-203-2c, in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma
This research study is studying a combination of targeted therapies known as GO-203-2C and bortezomib as a possible treatment for multiple myeloma that has either progressed or not responded to treatment.
A Phase 1, Multi-center, Open-label, Dose-escalation, Safety, Pharmacodynamic and Pharmacokinetic Study of GO-203-2c Given Intravenously Daily X21 Repeated Every 28 Days in Patients With Advanced Solid Tumors Including Lymphomas
This clinical trial is about testing GO-203-2c, which is a newly discovered compound that binds to an oncoprotein (a cancer causing protein) called MUC1 (which is over-expressed in many cancers). By binding to MUC1, GO-203-2c eventually causes tumor cell death in laboratory studies.
This study is being done to:
Test the safety of GO-203-2c and see what effects (good and bad) it has on you and your cancer
Find the highest dose of GO-203-2c that can be given without causing bad side effects
Examine how much GO-203-2c is in the blood at certain times after it is given and how quickly the body gets rid of it
Observe whether there is any effect of GO-203-2c on the size and activity of cancer in your body
100 Clinical Results associated with Genus Oncology LLC
0 Patents (Medical) associated with Genus Oncology LLC
24 Sep 2021·Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of The SIRPα-CD47 immune checkpoint in NK cells.
Author: Kharbanda, Surender
02 Jun 2021·Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Novel SIRPα Antibodies That Induce Single-Agent Phagocytosis of Tumor Cells while Preserving T Cells.
Author: Kharbanda, Surender
05 Jun 2020·Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Author: Garg, Abhishek ; Kharbanda, Surender
100 Deals associated with Genus Oncology LLC
100 Translational Medicine associated with Genus Oncology LLC